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Multi-Biomarkers' Responses in Gills of Oreochromis niloticus Exposed to Glyphosate and Polyethylene Microplastic, Isolated and in Mixture.
Soares, Marco Aurélio Miranda; Ferreira, Ericsson Rubens Rodrigues; Tavares, Driele; Moron, Sandro Estevan; Fernandes, Marisa Narciso; Mariano, Wagner Dos Santos; Paulino, Marcelo Gustavo.
Afiliación
  • Soares MAM; Laboratory of Morphophysiology and Biochemistry of Neotropical Fishes, Center of Agrarian Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil.
  • Ferreira ERR; Laboratory of Morphophysiology and Biochemistry of Neotropical Fishes, Center of Agrarian Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil.
  • Tavares D; Laboratory of Zoophysiology and Comparative Biochemistry, Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Moron SE; Laboratory of Morphophysiology and Biochemistry of Neotropical Fishes, Center of Agrarian Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil.
  • Fernandes MN; Laboratory of Zoophysiology and Comparative Biochemistry, Department of Physiological Sciences, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Mariano WDS; Laboratory of Comparative Animal Morphophysiology, Center of Integrated Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil.
  • Paulino MG; Laboratory of Comparative Animal Morphophysiology, Center of Integrated Sciences, Federal University of Northern Tocantins, Araguaína, Tocantins, Brazil.
Environ Toxicol ; 2024 Jul 25.
Article en En | MEDLINE | ID: mdl-39051743
ABSTRACT
Microplastics (MPs) and glyphosate-based herbicides (GBH) are among the most common contaminants in aquatic environments. In Brazilian rivers, both contaminants were found in elevated levels, leading to a high probability of their association, which can alter their individual effects and potentially intensify their toxicity. This study evaluated the isolated and combined effects of polyethylene microplastics (PE-MPs) and GBH on Oreochromis niloticus using multi-biomarkers of toxicity. The fish were subjected to a 96-h exposure period, with concentrations set based either isolated, PE-MPs group (5 mg L-1), GBH group (5 mg L-1), or in a group of associated contaminants (GAC), PE-MP + GBH (5 mg L-1 + 5 mg L-1). Toxicity effects were evaluated using biochemical, cytogenetic, hematological, and histopathological biomarkers. We observed change in erythrocyte parameters leading to macrocytic normochromic anemia in GAC. Leukocyte parameters indicate a nonspecific immunosuppression caused by the exposure of associated contaminants, besides the attempts to repair damage caused by PE-MPs. Histopathological markers indicate damage to tissues exposed to contaminants. Besides, there were morphophysiological adjustments on gills, with proliferation and hypertrophy of mitochondria-rich cells on GBH and GAC, besides epithelium ruptures, which were mostly present in the exposed groups. Therefore, this study indicates that PE-MPs and GBHs present toxic effects in O. niloticus with the used concentrations, intensified by the association of contaminants. Thus, multi-biomarkers were useful key to verify toxicity, providing data to the investigation of high levels of contaminant's mixture toxicity present in aquatic environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos