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Antioxidant and Antibacterial Screening and Hg(II) Sensing, Activities of Cu(II)pyridine-2,6-dicarboxylate Complexes.
Ur Rahman, Hameed; Khan, Ezzat; Muhammad, Mian; Khan, Maaz; Ahmad Bhat, Mashooq; Shahzada Khan, Gul; Ali, Nisar.
Afiliación
  • Ur Rahman H; Department of Chemistry, University of Malakand, 18800, Chakdara, Dir (Lower), Khyber, Pakhtunkhwa, Pakistan.
  • Khan E; Department of Chemistry, University of Malakand, 18800, Chakdara, Dir (Lower), Khyber, Pakhtunkhwa, Pakistan.
  • Muhammad M; Department of Chemistry, College of Science, University of Bahrain, Main Campus, 32038, Sakhir, Kingdom of Bahrain.
  • Khan M; Department of Chemistry, University of Malakand, 18800, Chakdara, Dir (Lower), Khyber, Pakhtunkhwa, Pakistan.
  • Ahmad Bhat M; Department of Chemistry, University of Malakand, 18800, Chakdara, Dir (Lower), Khyber, Pakhtunkhwa, Pakistan.
  • Shahzada Khan G; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
  • Ali N; Department of Chemistry, College of Science, University of Bahrain, Main Campus, 32038, Sakhir, Kingdom of Bahrain.
ChemistryOpen ; : e202400089, 2024 Jul 25.
Article en En | MEDLINE | ID: mdl-39051714
ABSTRACT
In this study five different complexes of Cu(II) were synthesized for the purpose of environmentally notorious mercury sensing and preliminary biological screening. Pyridine-2,6-dicarboxylic acid (also known as dipicolinic acid, and abbreviated as H2DPA), 3-phenyl pyrazole (3-ppz), 4-iodo-1H-pyrazole (4-ipz), 4-nitropyrazole (4-npz), 4-bromopyrazole (4-bpz), and 4-chloropyrazole (4-cpz) were chosen as potential ligands. The synthesized complexes labelled as 1-5, namely [Cu(DPA)(3-ppz)], [Cu(DPA)(4-ipz)], [Cu(DPA)(4-npz)], [Cu(DPA)(4-bpz)], [Cu(DPA)(4-cpz)], were proposed based on spectroscopic data (FTIR, TGA, and UV-visible spectroscopy). These complexes feature C=O functionalities that are not involved in coordination and may be used for further applications. The isolated complexes were utilized for detecting Hg(II) ions in water samples. Various concentrations of Hg(II) ions were prepared for detection purposes, and changes in absorption concerning complexes 1-5 were determined using UV-Visible spectroscopy. It was found that complexes 3 and 4 exhibit efficient sensing abilities towards Hg(II) ions. The antibacterial activities of complexes 1-5 were assessed against S. typhi and E. coli. The complexes 1 and 3 displayed good antibacterial activities against S. typhi (13.67, and 13.56 mm, respectively) while complexes 1, 2 and 4 were found to be efficient against E. coli (11.6, 12.66, 11.31 mm, respectively). The absorption maxima of 2,2-diphenyl-1-picryhydrazyl (DPPH) at 517 nm, considerably shifted upon addition of complexes 1-5. The results reveal that the complexes possess potential free radical scavenging abilities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ChemistryOpen Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ChemistryOpen Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Alemania