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A Machine Learning-Based Web Tool for the Severity Prediction of COVID-19.
Christodoulou, Avgi; Katsarou, Martha-Spyridoula; Emmanouil, Christina; Gavrielatos, Marios; Georgiou, Dimitrios; Tsolakou, Annia; Papasavva, Maria; Economou, Vasiliki; Nanou, Vasiliki; Nikolopoulos, Ioannis; Daganou, Maria; Argyraki, Aikaterini; Stefanidis, Evaggelos; Metaxas, Gerasimos; Panagiotou, Emmanouil; Michalopoulos, Ioannis; Drakoulis, Nikolaos.
Afiliación
  • Christodoulou A; Research Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  • Katsarou MS; Sotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
  • Emmanouil C; Research Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  • Gavrielatos M; Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
  • Georgiou D; Department of Biology, National and Kapodistrian University of Athens, 15772 Athens, Greece.
  • Tsolakou A; Institute for Bioinnovation, Biomedical Sciences Research Center 'Alexander Fleming', 16672 Vari, Greece.
  • Papasavva M; Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
  • Economou V; Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, 16122 Athens, Greece.
  • Nanou V; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Nikolopoulos I; Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
  • Daganou M; School of Electrical and Computer Engineering, National and Technical University of Athens, 15773 Athens, Greece.
  • Argyraki A; Research Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  • Stefanidis E; Department of Pharmacy, School of Health Sciences, Frederick University, 1036 Nicosia, Cyprus.
  • Metaxas G; Research Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  • Panagiotou E; Sotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
  • Michalopoulos I; Sotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
  • Drakoulis N; Sotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
BioTech (Basel) ; 13(3)2024 Jul 01.
Article en En | MEDLINE | ID: mdl-39051337
ABSTRACT
Predictive tools provide a unique opportunity to explain the observed differences in outcome between patients of the COVID-19 pandemic. The aim of this study was to associate individual demographic and clinical characteristics with disease severity in COVID-19 patients and to highlight the importance of machine learning (ML) in disease prognosis. The study enrolled 344 unvaccinated patients with confirmed SARS-CoV-2 infection. Data collected by integrating questionnaires and medical records were imported into various classification machine learning algorithms, and the algorithm and the hyperparameters with the greatest predictive ability were selected for use in a disease outcome prediction web tool. Of 111 independent features, age, sex, hypertension, obesity, and cancer comorbidity were found to be associated with severe COVID-19. Our prognostic tool can contribute to a successful therapeutic approach via personalized treatment. Although at the present time vaccination is not considered mandatory, this algorithm could encourage vulnerable groups to be vaccinated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioTech (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioTech (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza