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Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.
Ribeiro, Daniel Araki; da Silva, Glenda Nicioli; Malacarne, Ingra Tais; Pisani, Luciana Pellegrini; Salvadori, Daisy Maria Favero.
Afiliación
  • Ribeiro DA; Department of Biosciences, Federal University of Sao Paulo-UNIFESP, Santos 11015-020, SP, Brazil.
  • da Silva GN; Department of Clinical Analysis, Federal University of Ouro Preto-UFOP, Ouro Preto 35402-163, MG, Brazil.
  • Malacarne IT; Department of Biosciences, Federal University of Sao Paulo-UNIFESP, Santos 11015-020, SP, Brazil.
  • Pisani LP; Department of Biosciences, Federal University of Sao Paulo-UNIFESP, Santos 11015-020, SP, Brazil.
  • Salvadori DMF; Department of Pathology, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu 18618-687, SP, Brazil.
Pathophysiology ; 31(3): 352-366, 2024 Jul 04.
Article en En | MEDLINE | ID: mdl-39051223
ABSTRACT
Obesity is a big public health problem that claims several thousand lives every year. Bariatric surgery has arisen as a suitable procedure for treating obesity, particularly morbid obesity. Oxidative stress, genotoxicity, apoptosis, and inflammatory responses are recognized as the most important occurrences in carcinogenesis, as they actively contribute to the multistep process. This study aimed to briefly review the connection between oxidative stress, genotoxicity, apoptosis, and inflammation in obese patients undergoing bariatric surgery, focusing on its impact on carcinogenesis. Regarding oxidative stress, bariatric surgery may inhibit the synthesis of reactive oxygen species. Moreover, a significant reduction in the inflammatory status after weight loss surgery was not observed. Bariatric surgery prevents apoptosis in several tissues, but the maintenance of low body weight for long periods is mandatory for mitigating DNA damage. In conclusion, the association between bariatric surgery and cancer risk is still premature. However, further studies are yet needed to elucidate the real association between bariatric surgery and a reduced risk of cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathophysiology Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathophysiology Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza