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COVID-19 Vaccine in Lung and Liver Transplant Recipients Exceeds Expectations: An Italian Real-Life Experience on Immunogenicity and Clinical Efficacy of BNT162b2 Vaccine.
Morlacchi, Letizia Corinna; Alicandro, Gianfranco; Uceda Renteria, Sara; Zignani, Nunzio; Giacomel, Giovanni; Rossetti, Valeria; Sagasta, Michele; Citterio, Gaia; Lombardi, Andrea; Dibenedetto, Clara; Antonelli, Barbara; Rosso, Lorenzo; Lampertico, Pietro; Ceriotti, Ferruccio; Blasi, Francesco; Donato, Maria Francesca.
Afiliación
  • Morlacchi LC; Respiratory Unit and Adult Cystic, Fibrosis Centre, Internal Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Alicandro G; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.
  • Uceda Renteria S; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.
  • Zignani N; Department of Pediatrics, Cystic Fibrosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Giacomel G; Division of Clinical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Rossetti V; Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Sagasta M; Division of Clinical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Citterio G; Respiratory Unit and Adult Cystic, Fibrosis Centre, Internal Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Lombardi A; Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Dibenedetto C; Respiratory Unit and Adult Cystic, Fibrosis Centre, Internal Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Antonelli B; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.
  • Rosso L; Department of Pediatrics, Cystic Fibrosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Lampertico P; Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
  • Ceriotti F; General Surgery-Liver Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
  • Blasi F; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy.
  • Donato MF; Thoracic Surgery and Lung Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
Transpl Int ; 37: 12729, 2024.
Article en En | MEDLINE | ID: mdl-39050189
ABSTRACT
This study assessed humoral and T cell-mediated immune responses to the BNT162b2 vaccine in orthotopic liver transplant (OLT) and lung transplant (LUT) recipients who received three doses of the vaccine from March 2021 at our institution. Serum samples were collected 60 days post-second and third dose to quantify antibodies against the spike region of SARS-CoV-2 while whole blood samples were collected to analyze the SARS-CoV-2-specific T-cell response using an IFN-γ ELISpot assay. We enrolled 244 OLT and 120 LUT recipients. The third dose increased antibody titres in OLT recipients (from a median value of 131 after the second dose to 5523 IU/mL, p < 0.001) and LUT recipients (from 14.8 to 1729 IU/mL, p < 0.001). T-cell response also increased in OLT recipients (from 8.5 to 23 IFN-γ SFU per 250,000 PBMC, p < 0.001) and LUT recipients (from 8 to 15 IFN-γ SFU per 250,000 PBMC, p < 0.001). A total of 128 breakthrough infections were observed two (0.8%) OLT recipients were hospitalized due to COVID-19 and one died (0.4%); among LUT recipients, seven were hospitalized (5.8%) and two patients died (1.7%). In conclusion, the three-dose schedule of the BNT162b2 vaccine elicited both humoral and T cell-mediated responses in solid organ transplant recipients. The risk of severe COVID-19 post-vaccination was low in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Hígado / Trasplante de Pulmón / SARS-CoV-2 / COVID-19 / Vacuna BNT162 / Anticuerpos Antivirales Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Transpl Int Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Hígado / Trasplante de Pulmón / SARS-CoV-2 / COVID-19 / Vacuna BNT162 / Anticuerpos Antivirales Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Transpl Int Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza