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The cellular and molecular targets of natural products against metabolic disorders: a translational approach to reach the bedside.
Shen, Xiaofei; Yang, Hongling; Yang, Yang; Zhu, Xianjun; Sun, Qingxiang.
Afiliación
  • Shen X; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese Medicine Chengdu University of Traditional Chinese Medicine Chengdu China.
  • Yang H; Department of Nephrology and Institute of Nephrology Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Centre for Kidney Diseases Chengdu China.
  • Yang Y; Department of Respiratory and Critical Care Medicine Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China.
  • Zhu X; The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China.
  • Sun Q; Department of Respiratory and Critical Care Medicine Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China.
MedComm (2020) ; 5(8): e664, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39049964
ABSTRACT
Metabolic disorders, including obesity, dyslipidemia, diabetes, nonalcoholic fatty liver disease, and metabolic syndrome, are characterized by insulin resistance, abnormalities in circulating cholesterol and lipid profiles, and hypertension. The most common pathophysiologies of metabolic disorders are glucose/lipid metabolism dysregulation, insulin resistance, inflammatory response, and oxidative stress. Although several agents have been approved for the treatment of metabolic disorders, there is still a strong demand for more efficacious drugs with less side effects. Natural products have been critical sources of drug research and discovery for decades. However, the usefulness of bioactive natural products is often limited by incomplete understanding of their direct cellular targets. In this review, we highlight the current understanding of the established and emerging molecular mechanisms of metabolic disorders. We further summarize the therapeutic effects and underlying mechanisms of natural products on metabolic disorders, with highlights on their direct cellular targets, which are mainly implicated in the regulation of glucose/lipid metabolism, insulin resistance, metabolic inflammation, and oxidative stress. Finally, this review also covers the clinical studies of natural products in metabolic disorders. These progresses are expected to facilitate the application of these natural products and their derivatives in the development of novel drugs against metabolic disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedComm (2020) Año: 2024 Tipo del documento: Article Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedComm (2020) Año: 2024 Tipo del documento: Article Pais de publicación: China