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Efficacy of aprepitant for refractory pruritus in patients with epidermolysis bullosa and atopic dermatitis: A retrospective study.
Hartzell, Cheryl J; Szabova, Alexandra; Collins, Andrew B; Morel, Armand N; Mijatovic, Desimir; Goldschneider, Kenneth R.
Afiliación
  • Hartzell CJ; Pain Management Center, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
  • Szabova A; Pain Management Center, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
  • Collins AB; Pain Management Center, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
  • Morel AN; Pain Management Center, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
  • Mijatovic D; Pain Management Center, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
  • Goldschneider KR; Pain Management Center, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
Pediatr Dermatol ; 41(5): 819-821, 2024.
Article en En | MEDLINE | ID: mdl-39049669
ABSTRACT

INTRODUCTION:

At a single-center pediatric hospital, the neurokinin-1 receptor antagonist aprepitant was used to treat refractory pruritus in epidermolysis bullosa (EB) and atopic dermatitis (AD).

METHODS:

Thirty-seven patients were included (24 EB patients, 13 AD patients), ages 10 months to 37 years.

RESULTS:

58% (14/24) of patients with EB and 85% (11/13) of patients with AD reported aprepitant was effective in decreasing their pruritus, with age-related differences in efficacy observed in EB patients, and access to the medication by insurance denial or availability of the drug as a barrier to use.

CONCLUSIONS:

Aprepitant shows promise in controlling refractory pruritus in pediatric EB and AD patients and deserves further study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prurito / Epidermólisis Ampollosa / Dermatitis Atópica / Aprepitant Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Pediatr Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prurito / Epidermólisis Ampollosa / Dermatitis Atópica / Aprepitant Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Pediatr Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos