Analysis of macular thickness and peripapillary retinal nerve fiber layer thickness in various ABO and Rh blood groups.
BMC Ophthalmol
; 24(1): 307, 2024 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-39048995
ABSTRACT
PURPOSE:
To determine the association between ABO and Rh blood groups with retinal structural indices including macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness.METHODS:
This cross-sectional study was conducted using convenience sampling in a tertiary referral eye hospital in Tehran, Iran. Study participants were referred to the hospital laboratory to test their blood group. Ocular examinations were performed including measurement of visual acuity, auto-refraction, subjective refraction, and slit-lamp biomicroscopy. Retinal imaging was carried out using Spectral-domain OCT under dilated papillary conditions.RESULTS:
Three hundred and twenty-eight individuals were recruited in this study. Of these, 219 (60.7%) were female and the mean age of the participants was 63.29 ± 5.57 years (range 56 to 83 years). According to the multiple linear regression model, the global peripapillary RNFL thickness [coefficient -3.05 (95% CI -5.30 to -0.74); P = 0.010] and peripapillary RNFL thickness in the superior [coefficient -4.65 (95% CI -8.40 to -0.89), P < 0.001] and inferior [coefficient -4.00 (95% CI -7.81 to -0.19); P = 0.040] quadrants were significantly thinner in individuals with blood type B compared to those with other ABO blood groups. The average [coefficient 12.69 (95% CI 4.12-21.64); P = 0.004) and central [coefficient 16.21 (95% 6.44-25.97); P = 0.001) macular thicknesses were significantly thicker in AB group compared to other blood groups. The average macular thickness was significantly thinner in Rh + compared to the Rh- group [coefficient -8.33 (95% CI -15.4 to -1.25); P = 0.021].CONCLUSION:
Retinal structural indices may be related to blood groups implying a genetic linkage. Considering the lack of consistency among various studies, larger trials are needed to explore the effect of ABO and Rh grouping on peripapillary RNFL and macular thicknesses.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Ganglionares de la Retina
/
Sistema del Grupo Sanguíneo ABO
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Tomografía de Coherencia Óptica
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Mácula Lútea
/
Fibras Nerviosas
Límite:
Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
BMC Ophthalmol
Asunto de la revista:
OFTALMOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Reino Unido