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Aptamer and sodium alginate decorated graphene oxide composite material with ion responsiveness for Low-density lipoprotein trapping.
Cao, Jianfang; Wang, Yuanshang; Jin, Linshi; Liu, Yaobo; Wang, Weiting; Du, Pengfei; Ma, Yanli.
Afiliación
  • Cao J; Institute of Food & Nutrition Science and Technology, Shandong Provincial Key Laboratory of Agro­Products Processing Technology, Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
  • Wang Y; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  • Jin L; College of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
  • Liu Y; Institute of Food & Nutrition Science and Technology, Shandong Provincial Key Laboratory of Agro­Products Processing Technology, Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
  • Wang W; Institute of Food & Nutrition Science and Technology, Shandong Provincial Key Laboratory of Agro­Products Processing Technology, Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture, Shandong Academy of Agricultural Sciences, Jinan 250100, China. Electronic address: caojian
  • Du P; Institute of Food & Nutrition Science and Technology, Shandong Provincial Key Laboratory of Agro­Products Processing Technology, Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
  • Ma Y; Institute of Food & Nutrition Science and Technology, Shandong Provincial Key Laboratory of Agro­Products Processing Technology, Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
J Chromatogr A ; 1731: 465166, 2024 Aug 30.
Article en En | MEDLINE | ID: mdl-39047445
ABSTRACT
The accumulation of excess Low-density lipoprotein (LDL) is strongly associated with the occurrence of heart failure, coronary artery disease and hypercholesterolaemia, and is a major factor in cardiovascular and cerebrovascular disease. Concerns about the ways to decrease LDL level have continuously arisen. In this study, an ionic stimulation-responsive composite (i.e., GO@Apt@SA) is prepared with modification of graphene oxide (GO) utilising LDL-aptamer (Apt) and sodium alginate (SA). The ion-responsive behaviour of GO@Apt@SA synergistically interacts with the specific recognition property of the aptamer, enabling adsorption of LDL with higher capacity and specificity. Under the optimal experimental conditions, the maximum adsorption capacity of GO@Apt@SA for LDL is 730.6 µg mg-1. Interestingly, the aptamer complementary chain could trigger the release of LDL with favourable elution efficiency, which competitively binds with LDL-specific aptamer to trigger LDL release. More importantly, GO@Apt@SA exhibits satisfactory adsorption performances for LDL in goat serum, meaning that the composite material and technology are available for the extraction of LDL from complex sample matrices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alginatos / Aptámeros de Nucleótidos / Grafito / Lipoproteínas LDL Límite: Animals Idioma: En Revista: J Chromatogr A Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alginatos / Aptámeros de Nucleótidos / Grafito / Lipoproteínas LDL Límite: Animals Idioma: En Revista: J Chromatogr A Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos