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Potential applications of macrophages in cancer immunotherapy.
Sadri, Maryam; Heidari, Sahel; Faridzadeh, Arezoo; Roozbehani, Mona; Toosi, Shirin; Mahmoudian, Reihaneh Alsadat; Hoseinzadeh, Akram; Salmani Fard, Mohammad Taha; Arab, Fahimeh Lavi; Fard, Soheil Rahmani; Faraji, Fatemeh.
Afiliación
  • Sadri M; Department of Immunology, Iran University of Medical Sciences, Shahid Hemmat Highway, P.O. Box: 1449614535, Tehran, Iran. Electronic address: m.sadr@tak.iums.ac.ir.
  • Heidari S; Department of Immunology, Iran University of Medical Sciences, Shahid Hemmat Highway, P.O. Box: 1449614535, Tehran, Iran. Electronic address: sahel.heidari@my.jcu.edu.au.
  • Faridzadeh A; Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad 1313199137, Iran. Electronic address: faridzadeha2@mums.ac.ir.
  • Roozbehani M; Vaccine Research Center, Iran University of Medical Sciences, Shahid Hemmat Highway, P.O. Box: 1449614535, Tehran, Iran. Electronic address: mona.roozbehani@yahoo.com.
  • Toosi S; Stem Cell and Regenerative Medicine Center, Mashhad University of Medical Science, Mashhad 1313199137, Iran. Electronic address: toosis@mums.ac.ir.
  • Mahmoudian RA; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad 1313199137, Iran. Electronic address: mahmoudianr2@mums.ac.ir.
  • Hoseinzadeh A; Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan 3513119111, Iran. Electronic address: Hoseinzadehak961@semums.ac.ir.
  • Salmani Fard MT; School of Biology, College of Science, University of Tehran, Faculty of Sciences, Enqelab Square, Tehran 1417614411, Iran. Electronic address: m.tahasalmanifard@ut.ac.ir.
  • Arab FL; Immunology Research center, Mashhad University of Medical Sciences, Mashhad 1313199137, Iran. Electronic address: laviaf@mums.ac.ir.
  • Fard SR; Antimicrobial Resistance Research Center, Institute of Immunology and Infection Diseases Iran University of Medical Sciences, Floor 3, Building no. 3, Hazrat-e Rasool General Hospital, Niyayesh St, Sattar Khan St, P.O. Box: 1445613131, Tehran, Iran. Electronic address: rahmanifard.s@mums.ac.ir.
  • Faraji F; Antimicrobial Resistance Research Center, Institute of Immunology and Infection Diseases Iran University of Medical Sciences, Floor 3, Building no. 3, Hazrat-e Rasool General Hospital, Niyayesh St, Sattar Khan St, P.O. Box: 1445613131, Tehran, Iran. Electronic address: faraji.fat@iums.ac.ir.
Biomed Pharmacother ; 178: 117161, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39047419
ABSTRACT
Immunotherapy has improved cancer treatment based on investigations of tumor immune escape. Manipulation of the immune system stimulates antitumor immune responses and blocks tumor immune escape routes. Genetically adoptive cell therapy, such as T cells, has yielded promising results for hematologic malignancies, but their application to solid tumors has been challenging. Macrophages have a wide broad of capabilities in regulating immune responses, homeostasis, and tissue development, as well as the ability to phagocyte, present antigens, and infiltrate the tumor microenvironment (TME). Given the importance of macrophages in cancer development, they could serve as novel tool for tumor treatment. Therefore, macrophages are used in different formats for direct and indirect targeting of tumor cells. This review summarized the available data on the various applications of macrophages in cancer immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microambiente Tumoral / Inmunoterapia / Macrófagos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2024 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microambiente Tumoral / Inmunoterapia / Macrófagos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Año: 2024 Tipo del documento: Article Pais de publicación: Francia