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4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Molecular Design to Synthesis.
Ma, Tengfei; Gao, Shuang; Zhao, Li-Xia; Ye, Fei; Fu, Ying.
Afiliación
  • Ma T; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.
  • Gao S; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.
  • Zhao LX; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, Northeast Agricultural University, Harbin 150030, China.
  • Ye F; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.
  • Fu Y; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, Northeast Agricultural University, Harbin 150030, China.
J Agric Food Chem ; 72(31): 17125-17137, 2024 Aug 07.
Article en En | MEDLINE | ID: mdl-39047218
ABSTRACT
Weed resistance is a critical issue in crop production. Among the known herbicides, 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are crucial for addressing weed resistance. HPPD inhibitors constitute a pivotal aspect of contemporary crop protection strategies. The advantages of these herbicides are their broad weed spectrum, flexible application, and excellent compatibility with other herbicides. They also exhibit satisfactory crop selectivity and low toxicity and are environmentally friendly. An increasing number of new HPPD inhibitors have been designed by combining computer-aided drug design with conventional design approaches. Herein, the molecular design and structural features of innovative HPPD inhibitors are reviewed to guide the development of new HPPD inhibitors possessing an enhanced biological efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Inhibidores Enzimáticos / Malezas / Herbicidas / 4-Hidroxifenilpiruvato Dioxigenasa Idioma: En Revista: J Agric Food Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Inhibidores Enzimáticos / Malezas / Herbicidas / 4-Hidroxifenilpiruvato Dioxigenasa Idioma: En Revista: J Agric Food Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos