Your browser doesn't support javascript.
loading
Flortaucipir PET uncovers relationships between tau and amyloid-ß in primary age-related tauopathy and Alzheimer's disease.
Josephs, Keith A; Tosakulwong, Nirubol; Weigand, Stephen D; Graff-Radford, Jonathan; Schwarz, Christopher G; Senjem, Matthew L; Machulda, Mary M; Kantarci, Kejal; Knopman, David S; Nguyen, Aivi; Reichard, R Ross; Dickson, Dennis W; Petersen, Ronald C; Lowe, Val J; Jack, Clifford R; Whitwell, Jennifer L.
Afiliación
  • Josephs KA; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Tosakulwong N; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
  • Weigand SD; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
  • Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
  • Senjem ML; Department of Information Technology, Mayo Clinic, Rochester, MN 55905, USA.
  • Machulda MM; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
  • Kantarci K; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
  • Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Nguyen A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
  • Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
  • Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
  • Jack CR; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
  • Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Sci Transl Med ; 16(757): eado8076, 2024 Jul 24.
Article en En | MEDLINE | ID: mdl-39047115
ABSTRACT
[18F]-Flortaucipir positron emission tomography (PET) is considered a good biomarker of Alzheimer's disease. However, it is unknown how flortaucipir is associated with the distribution of tau across brain regions and how these associations are influenced by amyloid-ß. It is also unclear whether flortaucipir can detect tau in definite primary age-related tauopathy (PART). We identified 248 individuals at Mayo Clinic who had undergone [18F]-flortaucipir PET during life, had died, and had undergone an autopsy, 239 cases of which also had amyloid-ß PET. We assessed nonlinear relationships between flortaucipir uptake in nine medial temporal and cortical regions, Braak tau stage, and Thal amyloid-ß phase using generalized additive models. We found that flortaucipir uptake was greater with increasing tau stage in all regions. Increased uptake at low tau stages in medial temporal regions was only observed in cases with a high amyloid-ß phase. Flortaucipir uptake linearly increased with the amyloid-ß phase in medial temporal and cortical regions. The highest flortaucipir uptake occurred with high Alzheimer's disease neuropathologic change (ADNC) scores, followed by low-intermediate ADNC scores, then PART, with the entorhinal cortex providing the best differentiation between groups. Flortaucipir PET had limited ability to detect PART, and imaging-defined PART did not correspond with pathologically defined PART. In summary, spatial patterns of flortaucipir mirrored the histopathological tau distribution, were influenced by the amyloid-ß phase, and were useful for distinguishing different ADNC scores and PART.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbolinas / Péptidos beta-Amiloides / Proteínas tau / Tauopatías / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbolinas / Péptidos beta-Amiloides / Proteínas tau / Tauopatías / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos