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Opioid analgesic dose and route conversion ratio studies: a scoping review to inform an eDelphi guideline.
Davis, Mellar P; Davies, Andrew; McPherson, Mary Lynn; Reddy, Akhila; Paice, Judith A; Roeland, Eric; Walsh, Declan; Mercadante, Sebastiano; Case, Amy; Arnold, Robert; Satomi, Eriko; Crawford, Gregory; Bruera, Eduardo; Ripamonti, Carla.
Afiliación
  • Davis MP; Geisinger Medical Center, Danville, PA, 17821, USA. mdavis2@geisinger.edu.
  • Davies A; Trinity College Dublin, Dublin, Ireland.
  • McPherson ML; University of Maryland, Baltimore, ML, USA.
  • Reddy A; Palliative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Paice JA; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Roeland E; Oregon Health and Science University, Knight Cancer Institute, Portland, OR, USA.
  • Walsh D; Atrium Health, Levine Cancer Center, Charlotte, NC, USA.
  • Mercadante S; La Maddalena Cancer Center, Palermo, Italy.
  • Case A; Roswell Park Comprehensive Cancer Center, Rochester, NY, USA.
  • Arnold R; Icahn School of Medicine at Mt Sinai, New York, NY, USA.
  • Satomi E; Department of Palliative Medicine, National Cancer Center Hospital, Tokyo, Japan.
  • Crawford G; Northern Adelaide Local Health Network, Adelaide, South Australia, Australia.
  • Bruera E; University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ripamonti C; Network Italiano Cure Di Supporto in Oncologia (NICSO), Università Degli Studi Di Brescia, Brescia, Italy.
Support Care Cancer ; 32(8): 542, 2024 Jul 24.
Article en En | MEDLINE | ID: mdl-39046534
ABSTRACT

BACKGROUND:

Clinicians regularly prescribe opioids to manage acute and chronic cancer pain, frequently to address acute postoperative pain, and occasionally to manage chronic non-cancer pain. Clinical efficacy may be suboptimal in some patients due to side effects and/or poor response, and opioid rotation/switching (conversions) is frequently necessary. Despite the widespread practice, opioid conversion ratios are inconsistent between clinicians, practices, and countries. Therefore, we performed a scoping systematic review of opioid conversion studies to inform an international eDelphi guideline.

METHODS:

To ensure a comprehensive review, we conducted a systematic search across multiple databases (OVID Medline, PsycINFO, Embase, EBM-Cochrane Database of Systematic Reviews and Registered Trials, LILACS, IMEMR, AIM, WPRIM) using studies published up to June 2022. Additionally, we performed hand and Google Scholar searches to verify the completeness of our findings. Our inclusion criteria encompassed randomized and non-randomized studies with no age limit, with only a few pediatric studies identified. We included studies on cancer, non-cancer, acute, and chronic pain. The level and grade of evidence were determined based on the Multinational Supportive Care in Cancer (MASCC) criteria.

RESULTS:

Our search yielded 21,118 abstracts, including 140 randomized (RCT) and 68 non-randomized (NRCT) clinical trials. We compared these results with recently published conversion ratios. Modest correlations were noted between published reviews and the present scoping systematic review.

CONCLUSION:

The present scoping systematic review found low-quality evidence to support an opioid conversion guideline. We will use these data, including conversion ratios and type and route of administration, to inform an eDelphi guideline.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor en Cáncer / Analgésicos Opioides Límite: Humans Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor en Cáncer / Analgésicos Opioides Límite: Humans Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania