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[Potential action mechanism of Yishen Tongluo Prescription on male infertility: An analysis based on network pharmacology].
Hao, Gao-Li; Sun, Zi-Xue; Fan, Li-Peng; Xu, Lei; Qin, Guo-Zheng.
Afiliación
  • Hao GL; Department of Andrology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210033, China.
  • Sun ZX; Department of Andrology, Henan Provincial Hospital of Traditional Chinese Medicine / The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China.
  • Fan LP; Department of Andrology, Henan Provincial Hospital of Traditional Chinese Medicine / The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China.
  • Xu L; Department of Andrology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210033, China.
  • Qin GZ; Department of Andrology, Henan Provincial Hospital of Traditional Chinese Medicine / The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China.
Zhonghua Nan Ke Xue ; 30(1): 51-59, 2024 Jan.
Article en Zh | MEDLINE | ID: mdl-39046414
ABSTRACT

OBJECTIVE:

To analyze the main active components and potential molecular mechanism of Yishen Tongluo Prescription (YTP) in the treatment of male infertility based on network pharmacological technology.

METHODS:

We searched and sorted the main active components of YTP and their individual potential targets in the databases of Systematic Pharmacology of Traditional Chinese Medicine (TCM) and Bioinformatics Analysis Tool of the Molecular Mechanism of TCM, and screened the targets related to male infertility diseases in the databases of Genecards, DisGeNET and OMIM. We made a Venn diagram by intersecting the predicted targets of YTP and those of male infertility diseases, constructed visualized networks for the association of the intersection targets and protein-protein interaction (PPI) using the Cytoscape software and STRING platform respectively, and conducted gene ontology (GO) and KEGG enrichment analyses using the DAVID database and R language "Cluster Profiler" software package respectively.

RESULTS:

A total of 99 active components, 250 targets of YTP, 4 397 targets of male infertility and 127 common targets were identified. GO analysis revealed that the biological processes of the common targets mainly included transcriptional regulation of RNA polymerase promoter Ⅱ, regulation of gene expressions, regulation of apoptosis, responses to estrogen, and cell responses to hypoxia. KEGG analysis showed significant enrichment of the common targets in the estrogen signaling pathway, cell apoptosis pathway, AGE-RAGE signaling pathway in diabetic complications, and TNF signaling pathway.

CONCLUSION:

Through network pharmacology, we identified the main active components of YTP and its multi-target and multi-pathway mechanism in the treatment of male infertility, which has paved the ground for animal and cell experiments in verifying the action mechanism of YTP on male infertility.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Farmacología en Red / Infertilidad Masculina Límite: Humans / Male Idioma: Zh Revista: Zhonghua Nan Ke Xue Asunto de la revista: MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Farmacología en Red / Infertilidad Masculina Límite: Humans / Male Idioma: Zh Revista: Zhonghua Nan Ke Xue Asunto de la revista: MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China