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Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent.
Li, Li; Hajam, Irshad; McGee, Jean S; Tang, Zhengkuan; Zhang, Ye; Badey, Nikil; Mintzer, Esther; Zhang, Zhenrui; Liu, George Y; Church, George M; Wang, Yu.
Afiliación
  • Li L; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Hajam I; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • McGee JS; Department of Pediatrics, School of Medicine, UC San Diego, San Diego, California, USA.
  • Tang Z; Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Zhang Y; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Badey N; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Mintzer E; School of Public Health, Harvard University, Boston, Massachusetts, USA.
  • Zhang Z; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Liu GY; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Church GM; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Wang Y; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
Exp Dermatol ; 33(7): e15145, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39046322
ABSTRACT
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular parallels and disparities among these three disorders can yield invaluable insights for refined diagnostics, effective management, and targeted therapeutic interventions. In this report, we present a comparative analysis of transcriptomic data across these three diseases, elucidating differentially expressed genes and enriched pathways specific to each ailment, as well as those shared among them. Specifically, we identified multiple zinc-binding proteins (SERPINA1, S100A7, S100A8, S100A9 and KRT16) as consistently highly upregulated genes across all three diseases. Our hypothesis suggests that these proteins could bind and sequester zinc, potentially leading to localized zinc deficiency and heightened inflammation. We identified high-dose dietary zinc as a promising therapeutic approach and confirmed its effectiveness through validation in an acne mouse model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Hidradenitis Supurativa / Acné Vulgar / Rosácea / Perfilación de la Expresión Génica Límite: Animals / Humans Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Hidradenitis Supurativa / Acné Vulgar / Rosácea / Perfilación de la Expresión Génica Límite: Animals / Humans Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca