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Subclinical hypothyroidism and metabolic syndrome in psychiatric patients: A systematic literature review and meta-analysis.
Aung, The The; Wah, Win; Chakraborti, Arnob; Garg, Vikas.
Afiliación
  • Aung TT; Launceston General Hospital, Launceston, Tasmania, Australia.
  • Wah W; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
  • Chakraborti A; Tasmanian Mental Health Service, Royal Hobart Hospital, Hobart, Tasmania, Australia.
  • Garg V; Acute Mental Health Unit, Darling Downs Hospital and Health Service, Toowoomba, Queensland, Australia.
Australas Psychiatry ; : 10398562241267149, 2024 Jul 24.
Article en En | MEDLINE | ID: mdl-39046130
ABSTRACT

OBJECTIVE:

The systematic review evaluated the association of subclinical hypothyroidism (SCH) with metabolic syndrome (MetS) and specific MetS components in people with major psychiatric disorders.

METHODS:

A systematic review and meta-analysis was conducted to evaluate the association of SCH with MetS and its components in people with major psychiatric conditions.

RESULTS:

Five studies incorporating 24,158 participants met the inclusion criteria. All five studies comprised patients with depression and/or anxiety. Three studies incorporating 3365 participants were suitable for the meta-analysis. The pooled Odds Ratio (OR) of MetS was 3.46 (95% Confidence Interval/CI = 1.39-8.62) in major depressive disorder (MDD) and anxiety disorders patients with concurrent SCH compared to those without SCH. Meta-analysis showed a significant positive association between SCH and high body mass index (OR = 2.58, 95%CI = 1.33-5.01), high fasting plasma glucose (OR = 3.05, 95%CI = 1.79-5.18) and low high-density lipoprotein cholesterol (OR = 2.30, 95%CI = 1.82-2.92).

CONCLUSIONS:

These findings suggest a significant positive association between MetS and SCH in people with MDD and anxiety disorders. This review informed the clinical implications of MetS in MDD with comorbid SCH and the importance of early diagnosis and treatment for SCH and MetS in psychiatric patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Australas Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Australas Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido