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Acute and Chronic Oral Toxicity of Hydroethanolic Extract of Sclerocarya birrea (Anacardiaceae) in Wistar Rats.
Coulidiaty, Abdul Gafar Victoir; Boni, Saamou Isaac; Ouedraogo, Raogo; Koama, Benjamin Kouliga; Soré, Harouna; Meda, Roland Nâg-Tiero; Yaméogo, Téné Marceline; Youl, Estelle Noëla Hoho.
Afiliación
  • Coulidiaty AGV; Laboratoire de Développement du Médicament, Ecole Doctorale Sciences et Santé (ED2S), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
  • Boni SI; Laboratoire de Recherche et d'Enseignement en Santé et Biotechnologies Animales, Université Nazi Boni, Bobo Dioulasso, Burkina Faso.
  • Ouedraogo R; Laboratoire de Développement du Médicament, Ecole Doctorale Sciences et Santé (ED2S), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
  • Koama BK; Laboratoire de Recherche et d'Enseignement en Santé et Biotechnologies Animales, Université Nazi Boni, Bobo Dioulasso, Burkina Faso.
  • Soré H; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.
  • Meda RN; Laboratoire de Recherche et d'Enseignement en Santé et Biotechnologies Animales, Université Nazi Boni, Bobo Dioulasso, Burkina Faso.
  • Yaméogo TM; Institut Supérieur des Sciences de la Santé, Université Nazi BONI, Bobo Dioulasso, Burkina Faso.
  • Youl ENH; Laboratoire de Développement du Médicament, Ecole Doctorale Sciences et Santé (ED2S), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
J Exp Pharmacol ; 16: 231-242, 2024.
Article en En | MEDLINE | ID: mdl-39045603
ABSTRACT

Background:

Sclerocarya birrea (A. Rich). Hochst, popularly known as Morula, is a plant in the Anacardiaceae family. The bark, fruits, and leaves have traditionally been used to manage a variety of health conditions, most especially diabetes. Unfortunately, there is a scarcity of data and publications on the toxicity and safety of this plant.

Purpose:

The current study was designed to assess the acute and chronic toxicity of a hydro-ethanolic extract of Sclerocarya birrea in albino rats. Materials and

Methods:

Sclerocarya birrea was extracted using an 80-20% hydro-ethanolic solution. For the acute toxicity study, female Wistar albino rats were treated with hydro-ethanolic leaf extract at a dose of 5000 mg/kg body weight and followed-up for 14 days. In the chronic toxicity study, 40 healthy Wistar albino rats were divided in 4 groups. The three treatment groups were administered the leaf hydro-ethanolic extract orally at dosages of 30, 150, and 1000 mg/kg once day for 90 days and the fourth group was a control group. Body and organs weights, haematological, serum biochemical, and histopathological parameters were measured at the end of the experiment.

Results:

Single-dose oral administration of hydro-ethanolic leaf extract of Sclerocarya birrea at 5000 mg/kg produced no mortality indicating the LD50 is greater than 5000 mg/kg body weight. Following 90 days of administration of a hydro-ethanolic extract of Sclerocarya birrea leaves, there was no significant change in body and organs weights. Furthermore, biochemical, haematological and histopathological parameters did not vary significantly.

Conclusion:

This data indicates neither acute or chronic toxicity in rats and is consistent with the widespread and long-term usage of Sclerocarya birrea in African traditional medicine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Exp Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Burquina Faso Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Exp Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: Burquina Faso Pais de publicación: Nueva Zelanda