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Paclitaxel-coated versus sirolimus-coated balloon angioplasty for coronary artery disease: A systematic review and meta-analysis.
Shin, Doosup; Singh, Mandeep; Shlofmitz, Evan; Scheller, Bruno; Latib, Azeem; Kandzari, David E; Zaman, Azfar; Mylotte, Darren; Dakroub, Ali; Malik, Sarah; Sakai, Koshiro; Jeremias, Allen; Moses, Jeffrey W; Shlofmitz, Richard A; Stone, Gregg W; Ali, Ziad A.
Afiliación
  • Shin D; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Singh M; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Shlofmitz E; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Scheller B; Clinical and Experimental Interventional Cardiology, University of Saarland, Homburg/Saar, Germany.
  • Latib A; Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Kandzari DE; Piedmont Heart Institute, Atlanta, Georgia, USA.
  • Zaman A; Department of Cardiology, Freeman Hospital and Newcastle University, Newcastle upon Tyne, UK.
  • Mylotte D; Department of Cardiology, University Hospital Galway, Galway, Ireland.
  • Dakroub A; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Malik S; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Sakai K; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Jeremias A; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Moses JW; Cardiovascular Research Foundation, New York, New York, USA.
  • Shlofmitz RA; Department of Cardiology, St Francis Hospital and Heart Center, Roslyn, New York, USA.
  • Stone GW; Cardiovascular Research Foundation, New York, New York, USA.
  • Ali ZA; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Catheter Cardiovasc Interv ; 2024 Jul 24.
Article en En | MEDLINE | ID: mdl-39044661
ABSTRACT

BACKGROUND:

Although use of sirolimus-based analogs has shown superiority over paclitaxel in drug-eluting stents, the relative efficacy of these two agents released from drug-coated balloons (DCB) is unclear. The present meta-analysis is aimed to compare outcomes after percutaneous coronary intervention (PCI) with paclitaxel-coated balloons (PCB) versus sirolimus-coated balloons (SCB) for either in-stent restenosis or native de novo lesions.

METHODS:

The study outcomes were 1) target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization, and 2) follow-up angiographic parameters including late lumen loss (LLL), diameter stenosis, and minimal lumen diameter (MLD). Pooled odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (CI) were calculated by using random-effects models.

RESULTS:

A search of PubMed, EMBASE, and Cochrane Library from their inception to January 2024 identified five randomized clinical trials and three observational studies with a total of 1861 patients (889 in PCB and 972 in SCB groups). During 9-12 months of follow-up, there was no significant difference in TLF (OR 1.01, 95% CI 0.75-1.35) between the two groups. On follow-up angiography at 6-9 months, MLD (WMD 0.10, 95% CI 0.02-0.17) was larger in PCB but there was no statistically significant difference in LLL (WMD -0.11, 95% CI -0.23-0.02) and diameter stenosis (WMD -3.33, 95% CI -8.11-1.45).

CONCLUSIONS:

Among patients undergoing DCB-only PCI, the risk of TLF was similar during 9-12 months of follow-up after PCB and SCB treatment. However, the MLD was larger favoring PCB over SCB on follow-up angiography.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Catheter Cardiovasc Interv Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Catheter Cardiovasc Interv Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos