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Corticospinal excitability at rest outside of a task does not differ from task intertrial intervals in healthy adults.
Bakken, Kate; Horton, Chris; Fisher, Mitchell; Wadsley, Corey G; Greenhouse, Ian.
Afiliación
  • Bakken K; Action Control Lab, Department of Human Physiology, University of Oregon, Eugene, OR, USA.
  • Horton C; Action Control Lab, Department of Human Physiology, University of Oregon, Eugene, OR, USA.
  • Fisher M; Action Control Lab, Department of Human Physiology, University of Oregon, Eugene, OR, USA.
  • Wadsley CG; Action Control Lab, Department of Human Physiology, University of Oregon, Eugene, OR, USA.
  • Greenhouse I; Action Control Lab, Department of Human Physiology, University of Oregon, Eugene, OR, USA. img@uoregon.edu.
Exp Brain Res ; 242(9): 2263-2270, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39043898
ABSTRACT
Human corticospinal excitability (CSE) modulates during movement, when muscles are active, but also at rest, when muscles are not active. These changes in resting motor system excitability can be transient or longer lasting. Evidence from transcranial magnetic stimulation (TMS) studies suggests even relatively short periods of motor learning on the order of minutes can have lasting effects on resting CSE. Whether individuals are able to return CSE to out-of-task resting levels during the intertrial intervals (ITI) of behavioral tasks that do not include an intended motor learning component is an important question. Here, in twenty-five healthy young adults, we used single-pulse TMS and electromyography (EMG) to measure motor evoked potentials (MEPs) during two different resting contexts (1) prior to engaging in the response task during which participants were instructed only to rest (out-of-task), and (2) ITI of a choice-reaction time task (in-task). In both contexts, five TMS intensities were used to evaluate possible differences in recruitment of corticospinal (CS) output across a range of inputs. We hypothesized resting state CSE would be greater during ITI than out-of-task rest, reflected in larger MEP amplitudes. Contrary to our hypothesis, we observed no significant difference in MEP amplitudes between out-of-task rest and in-task ITI, and instead found evidence of equivalence, indicating that humans are able to return to a stable motor resting state within seconds after a response. These data support the interpretation that rest is a uniform motor state in the healthy nervous system. In the future, our data may be a useful reference for motor disorder populations with an impaired ability to return to rest.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tractos Piramidales / Descanso / Potenciales Evocados Motores / Electromiografía / Estimulación Magnética Transcraneal Límite: Adult / Female / Humans / Male Idioma: En Revista: Exp Brain Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tractos Piramidales / Descanso / Potenciales Evocados Motores / Electromiografía / Estimulación Magnética Transcraneal Límite: Adult / Female / Humans / Male Idioma: En Revista: Exp Brain Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania