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Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy.
Crespo Pimentel, Bernardo; Kuchukhidze, Giorgi; Xiao, Fenglai; Caciagli, Lorenzo; Höfler, Julia; Rainer, Lucas; Kronbichler, Martin; Vollmar, Christian; Duncan, John S; Trinka, Eugen; Koepp, Matthias; Wandschneider, Britta.
Afiliación
  • Crespo Pimentel B; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria bcpimentel93@gmail.com b.wandschneider@ucl.ac.uk.
  • Kuchukhidze G; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
  • Xiao F; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria.
  • Caciagli L; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK.
  • Höfler J; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria.
  • Rainer L; Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Salzburg, Austria.
  • Kronbichler M; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
  • Vollmar C; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK.
  • Duncan JS; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.
  • Trinka E; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire, UK.
  • Koepp M; Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Wandschneider B; Department of Neurology, Neurointensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Salzburg, Austria.
J Neurol Neurosurg Psychiatry ; 2024 Jul 23.
Article en En | MEDLINE | ID: mdl-39043568
ABSTRACT

BACKGROUND:

Juvenile myoclonic epilepsy (JME) is associated with cortical thinning of the motor areas. The relative contribution of antiseizure medication to cortical thickness is unknown. We aimed to investigate how valproate influences the cortical morphology of JME.

METHODS:

In this cross-sectional study, individuals with JME with and without valproate, with temporal lobe epilepsy (TLE) with valproate and controls were selected through propensity score matching. Participants underwent T1-weighted brain imaging and vertex-wise calculation of cortical thickness.

RESULTS:

We matched 36 individuals with JME on valproate with 36 individuals with JME without valproate, 36 controls and 19 individuals with TLE on valproate. JME on valproate showed thinning of the precentral gyri (left and right, p<0.001) compared with controls and thinning of the left precentral gyrus when compared with JME not on valproate (p<0.01) or to TLE on valproate (p<0.001). Valproate dose correlated negatively with the thickness of the precentral gyri, postcentral gyri and superior frontal gyrus in JME (left and right p<0.0001), but not in TLE.

CONCLUSIONS:

Valproate was associated with JME-specific and dose-dependent thinning of the cortical motor regions. This suggests that valproate is a key modulator of cortical morphology in JME, an effect that may underlie its high efficacy in this syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Neurol Neurosurg Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Neurol Neurosurg Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido