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The activities of suaveolol and other compounds from Hyptis suaveolens and Momordica charantia against the aetiological agents of African trypanosomiasis, leishmaniasis and malaria.
Oaikhena, Enimie E; Yahaya, Umar A; Abdulsalami, Sani M; Egbe, Nkechi L; Adeyemi, Modupe M; Ungogo, Marzuq A; Ebiloma, Godwin U; Zoiku, Felix K; Fordjour, Prince A; Elati, Hamza A A; Quashie, Neils B; Igoli, John O; Gray, Alexander I; Lawson, Christopher; Ferro, Valerie A; de Koning, Harry P.
Afiliación
  • Oaikhena EE; Department of Biotechnology, Nigerian Defence Academy, PMB 2109, Kaduna, Kaduna State, Nigeria.
  • Yahaya UA; Department of Biological Sciences, Nigerian Defence Academy, PMB 2109, Kaduna, Kaduna State, Nigeria.
  • Abdulsalami SM; Department of Biotechnology, Nigerian Defence Academy, PMB 2109, Kaduna, Kaduna State, Nigeria.
  • Egbe NL; Department of Biotechnology, Nigerian Defence Academy, PMB 2109, Kaduna, Kaduna State, Nigeria.
  • Adeyemi MM; Department of Chemistry, Nigerian Defence Academy, Kaduna, Kaduna State, Nigeria.
  • Ungogo MA; Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, EH8 PYL, UK.
  • Ebiloma GU; School of Science, Engineering & Environment, University of Salford, M5 4NT, Manchester, UK.
  • Zoiku FK; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Fordjour PA; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Elati HAA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Department of Pharmacology and Toxicology, Pharmacy College, University of Elmergib, Al Khums, Libya.
  • Quashie NB; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Ghana; Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Ghana.
  • Igoli JO; Department of Chemistry, Joseph Sarwuan Tarka University, PMB 2373, Makurdi, Benue State, Nigeria; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, G4 0RE, UK.
  • Gray AI; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, G4 0RE, UK.
  • Lawson C; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, G4 0RE, UK.
  • Ferro VA; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, G4 0RE, UK.
  • de Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: Harry.de-Koning@glasgow.ac.uk.
Exp Parasitol ; 263-264: 108807, 2024.
Article en En | MEDLINE | ID: mdl-39043327
ABSTRACT
African trypanosomiasis and malaria are among the most severe health challenges to humans and livestock in Africa and new drugs are needed. Leaves of Hyptis suaveolens Kuntze (Lamiaceae) and Momordica charantia L. (Cucurbitaceae) were extracted with hexane, ethyl acetate, and then methanol, and subjected to silica gel column chromatography. Structures of six isolated compounds were elucidated through NMR and HR-EIMS spectrometry. Callistrisic acid, dehydroabietinol, suaveolic acid, suaveolol, and a mixture of suaveolol and suaveolic acid (SSA) were obtained from H. suaveolens, while karavilagenin D and momordicin I acetate were obtained from M. charantia. The isolated biomolecules were tested against trypomastigotes of Trypanosoma brucei brucei and T. congolense, and against Plasmodium falciparum. The most promising EC50 values were obtained for the purified suaveolol fraction, at 2.71 ± 0.36 µg/mL, and SSA, exhibiting an EC50 of 1.56 ± 0.17 µg/mL against T. b. brucei trypomastigotes. Suaveolic acid had low activity against T. b. brucei but displayed moderate activity against T. congolense trypomastigotes at 11.1 ± 0.5 µg/mL. Suaveolol and SSA were also tested against T. evansi, T. equiperdum, Leishmania major and L. mexicana but the antileishmanial activity was low. Neither of the active compounds, nor the mixture of the two, displayed any cytotoxic effect on human foreskin fibroblast (HFF) cells at even the highest concentration tested, being 200 µg/mL. We conclude that suaveolol and its mixture possessed significant and selective trypanocidal activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Trypanosoma brucei brucei / Extractos Vegetales / Hojas de la Planta / Momordica charantia / Hyptis Límite: Animals / Humans Idioma: En Revista: Exp Parasitol Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Trypanosoma brucei brucei / Extractos Vegetales / Hojas de la Planta / Momordica charantia / Hyptis Límite: Animals / Humans Idioma: En Revista: Exp Parasitol Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Estados Unidos