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Intraoperative DBS targeting of the globus pallidus internus by using motor evoked potentials.
Trenado, Carlos; Nikolov, Petyo; Slotty, Philipp J; Vesper, Jan; Schnitzler, Alfons; Groiss, Stefan Jun.
Afiliación
  • Trenado C; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Max Planck Institute for Empirical Aesthetics, Frankfurt am Main, Germany.
  • Nikolov P; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Slotty PJ; Department of Orthopaedics, Trauma Surgery and Hand Unit, Helios Klinikum Krefeld, Krefeld, Germany; Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Faculty of Medicine, Heinrich Heine University, Düsseldorf, Germany.
  • Vesper J; Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Schnitzler A; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Groiss SJ; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Neurocenter Düsseldorf, Düsseldorf, Germany. Electronic address: groiss@uni-duesseldor
J Neurol Sci ; 463: 123141, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39043070
ABSTRACT

OBJECTIVES:

Target localization for deep brain stimulation (DBS) is a crucial step that influences the clinical benefit of the DBS procedure together with the reduction of side effects. In this work, we address the feasibility of DBS target localization in the globus pallidus internus (GPi) aided by intraoperative motor evoked potentials (MEP) with emphasis on the reduction of capsular side effects. MATERIAL AND

METHODS:

Micro-macroelectrode recordings were performed intraoperatively on 20 patients that underwent DBS treatment of the GPi (GPi-DBS). MEP were elicited intraoperatively by microelectrode stimulation during stereotactic DBS surgery. We studied the relationship between MEP thresholds and the internal capsule (IC) proximity.

RESULTS:

We found a significant correlation between intraoperative MEP thresholds and IC proximity.

CONCLUSIONS:

We provide further evidence of the role of MEPs for DBS target localization in the GPi, which extends and confirms the usefulness of MEPs as previously reported by DBS target localization studies dealing with the subthalamic and thalamic nuclei. Our approach is advantageous in that it provides criteria to determine the DBS target without the need to rely on a patient's response while avoiding capsular effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales Evocados Motores / Estimulación Encefálica Profunda / Globo Pálido Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciales Evocados Motores / Estimulación Encefálica Profunda / Globo Pálido Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos