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Circular RNA oligonucleotides: enzymatic synthesis and scaffolding for nanoconstruction.
Li, Shijie; Chu, Yanxin; Guo, Xin; Mao, Chengde; Xiao, Shou-Jun.
Afiliación
  • Li S; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, Jiangsu, China.
  • Chu Y; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, Jiangsu, China.
  • Guo X; Bruker (Beijing) Scientific Technology Co. Ltd, China.
  • Mao C; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA. mao@purdue.edu.
  • Xiao SJ; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, Jiangsu, China.
Nanoscale Horiz ; 2024 Jul 23.
Article en En | MEDLINE | ID: mdl-39042106
ABSTRACT
We report the efficient synthesis of monomeric circular RNAs (circRNAs) in the size range of 16-44 nt with a novel DNA dumbbell splinting plus T4 DNA ligation strategy. Such a DNA dumbbell splinting strategy was developed by one group among ours recently for near-quantitative conversion of short linear DNAs into monomeric circular ones. Furthermore, using the 44 nt circRNA as scaffold strands, we constructed hybrid RNADNA and pure RNARNA double crossover tiles and their assemblies of nucleic acid nanotubes and flat arrays.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanoscale Horiz Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nanoscale Horiz Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido