Your browser doesn't support javascript.
loading
Prevalence and Factor Associated with Anti-N-Methyl-D-Aspartate Receptor Encephalitis Among Patients with Medical Conditions: A Systematic Review and Meta-Analysis.
Lee, Kai Wei; Khan, Abdul Hanif Khan Yusof; Ching, Siew Mooi; Kumar, Sathish Jaya; Raj, Charlene Lily Vincent Paul; Chia, Peck Kee; Basri, Hamidon; Sulaiman, Wan Aliaa Wan; Mat, Liyana Najwa Inche; Veettil, Sajesh K; Hoo, Fan Kee; Loh, Wei Chao.
Afiliación
  • Lee KW; Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Khan AHKY; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Ching SM; Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Kumar SJ; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Raj CLVP; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Chia PK; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Basri H; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Sulaiman WAW; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Mat LNI; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Veettil SK; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia, Kuala Lumpur, Malaysia.
  • Hoo FK; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  • Loh WC; Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Neurol India ; 72(3): 476-486, 2024 May 01.
Article en En | MEDLINE | ID: mdl-39041960
ABSTRACT

BACKGROUND:

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune encephalitis due to immune production of anti-NMDAR antibodies against the NR1 subunit of the NMDA receptor which is present throughout the central nervous system. This condition had been reported to be prevalent in patients with certain medical conditions; however so far, there have been limited systematic reviews and meta-analyses on the prevalence and factors associated.

OBJECTIVE:

This study was to determine the prevalence and factors associated with anti-NMDAR encephalitis among affected patients. MATERIAL AND

METHODS:

The protocol of this study has been registered (2019 CRD42019142002) with the International Prospective Register of Systematic Reviews (PROSPERO). The primary outcome was the incidence or prevalence of anti-NMDAR encephalitis and secondary outcomes were factors associated with anti-NMDAR encephalitis.

RESULTS:

There were 11 studies and a total of 873 million patients taken from high-risk populations across 11 countries that were included in the primary analysis. The overall pooled prevalence of anti-NMDAR encephalitis among patients with medical conditions was 7.0% (95% CI = 4.4, 9.6). Those with first episode of psychosis or schizophrenia were at a higher risk of developing anti-NMDAR encephalitis with an odds ratio of 5.976 (95% CI = 1.122, 31.825).

CONCLUSION:

We found that almost one-tenth of patients with medical conditions had anti-NMDAR encephalitis; particularly those with first episode of psychosis or schizophrenia were among the high-risk medical conditions.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalitis Antirreceptor N-Metil-D-Aspartato Límite: Humans Idioma: En Revista: Neurol India Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalitis Antirreceptor N-Metil-D-Aspartato Límite: Humans Idioma: En Revista: Neurol India Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: India