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[Chemical constituents from Clitocybe clavipes and their antitumor activities].
Lei, Qi-Jun; Lyu, Jie; Ma, Guo-Xu; Sun, Zhao-Cui; Xu, Xu-Dong; Wei, Hua; Shi, Lei-Ling; Lu, Yong-Man.
Afiliación
  • Lei QJ; Xinjiang University Urumqi 830046, China Xinjiang Institute of Traditional Chinese Medicine and Ethnic Medicine Urumqi 830002, China.
  • Lyu J; Xinjiang University Urumqi 830046, China.
  • Ma GX; Xinjiang Institute of Traditional Chinese Medicine and Ethnic Medicine Urumqi 830002, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Sun ZC; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Xu XD; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Wei H; Jishou University Jishou 416000, China.
  • Shi LL; Xinjiang Institute of Traditional Chinese Medicine and Ethnic Medicine Urumqi 830002, China.
  • Lu YM; Xinjiang University Urumqi 830046, China.
Zhongguo Zhong Yao Za Zhi ; 49(11): 2947-2952, 2024 Jun.
Article en Zh | MEDLINE | ID: mdl-39041154
ABSTRACT
This paper aimed to study the chemical constituents from Clitocybe clavipes. Silica gel, ODS, Sephadex LH-20, and semi-p reparative HPLC were employed to separate the ethanol extract of C. clavipes. Six compounds were identified by ~1H-NMR, ~(13)CNMR,and ESI-MS as clavilactone L(1), clavilactone A(2), clavilactone B(3), clavilactone E(4), clavilactone H(5), and clav ilactone I(6). Among them, compound 1 was a new meroterpenoid with a 10-membered carbocycle connected to a hydroquinone. Theantitumor activities of compounds 1-6 were determined by the methyl thiazolyl tetrazolium(MTT) ass ay. The results showed that compounds 1-6 exerted inhibitory effects on the proliferation of human gastric cancer cells(MGC-803),human non-small cell lung cancer cells(A549), and cervical cancer cells(HeLa). Compound 1 exhibited significant inhibitory activity against MGC-803 cells, with the half maximal inhibitory concentration(IC_(50)) of 11. 76 µmol·L~(-1).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proliferación Celular Límite: Humans Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proliferación Celular Límite: Humans Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China