Dataset on transcriptomic profiling of parenteral nutrition-induced hepatotoxicity in a human liver in vitro model.
Data Brief
; 55: 110653, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39040552
ABSTRACT
The provided dataset describes the transcriptomic profile of human liver spheroid co-cultures consisting of a human hepatoma cell line (C3A/HepG2 cells) and an immortalized activated human hepatic stellate cell line (LX-2 cells) upon exposure to total parenteral nutrition. High-throughput RNA sequencing was performed using DNBSEQTM sequencing technology. Following the quality check and filtering of raw sequence reads, the clean reads were aligned to the reference human genome and used to determine differential gene expression. Raw and processed data are deposited in the Gene Expression Omnibus with accession number GSE264357. These data could serve further mechanistic studies on parenteral nutrition-induced liver injury and support translational research on intestinal failure-associated liver disease occurring in individuals receiving total parenteral nutrition.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Data Brief
Año:
2024
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Países Bajos