Your browser doesn't support javascript.
loading
Preliminary investigation of nitric oxide release from upconverted nanoparticles excited at 808 nm near-infrared for brain tumors.
Li, Lei; Yang, Jiang-Hua; Fa, Xin-Meng; Liu, Ming-Song; Wang, Qi-Lin; Zeng, Tong-Fei; Chen, Rui-Zhe; Ou, Jun; Xia, Xue-Wei.
Afiliación
  • Li L; Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, 541001, Guilin, China.
  • Yang JH; Materials Science and Engineering College, Guilin University of Technology, 541004, Guilin, China.
  • Fa XM; Materials Science and Engineering College, Guilin University of Technology, 541004, Guilin, China.
  • Liu MS; Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, 541001, Guilin, China.
  • Wang QL; Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, 541001, Guilin, China.
  • Zeng TF; Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, 541001, Guilin, China.
  • Chen RZ; Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, 541001, Guilin, China.
  • Ou J; Materials Science and Engineering College, Guilin University of Technology, 541004, Guilin, China.
  • Xia XW; Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, 541001, Guilin, China.
Heliyon ; 10(13): e33576, 2024 Jul 15.
Article en En | MEDLINE | ID: mdl-39040363
ABSTRACT
Upconverted UCNPs@mSiO2-NH2 nanoparticles were synthesized via thermal decomposition while employing the energy resonance transfer principle and the excellent near-infrared (NIR) light conversion property of up-conversion. The 808 nm NIR-excited photocontrolled nitric oxide (NO) release platform was successfully developed by electrostatically loading photosensitive NO donor Roussin's black salt (RBS) onto UCNPs@mSiO2-NH2, enabling the temporal, spatial, and dosimetric regulation of NO release for biological applications of NO. The release of NO ranged from 0.015⁓0.099 mM under the conditions of 2.0 W NIR excitation power, 20 min of irradiation time, and UCNPs@mSiO2-NH2&RBS concentration of 0.25⁓1.25 mg/mL. Therefore, this NO release platform has an anti-tumor effect. In vitro experiments showed that under the NIR light, at concentrations of 0.3 mg/mL and 0.8 mg/mL of UCNPs@mSiO2-NH2&RBS, the activity of glioma (U87) and chordoma (U-CH1) cells, as measured by CCK8 assay, was reduced to 50 %. Cell flow cytometry and Western Blot experiments showed that NO released from UCNPs@mSiO2-NH2&RBS under NIR light induced apoptosis in brain tumor cells. In vivo experiments employing glioma and chordoma xenograft mouse models revealed significant inhibition of tumor growth in the NIR and UCNPs@mSiO2-NH2&RBS group, with no observed significant side effects in the mice. Therefore, NO released by UCNPs@mSiO2-NH2&RBS under NIR irradiation can be used as a highly effective and safe strategy for brain tumor therapy.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido