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Using machine learning-based algorithms to construct cardiovascular risk prediction models for Taiwanese adults based on traditional and novel risk factors.
Cheng, Chien-Hsiang; Lee, Bor-Jen; Nfor, Oswald Ndi; Hsiao, Chih-Hsuan; Huang, Yi-Chia; Liaw, Yung-Po.
Afiliación
  • Cheng CH; Department of Respiratory Therapy, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.
  • Lee BJ; Department of Critical Care Medicine, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.
  • Nfor ON; Department of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, Taichung City, 40201, Taiwan.
  • Hsiao CH; Department of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, Taichung City, 40201, Taiwan.
  • Huang YC; Department of Nutrition, Chung Shan Medical University and Chung Shan Medical University Hospital, No. 110, Sec. 1 Jianguo N. Rd, Taichung, 40201, Taiwan. ych@csmu.edu.tw.
  • Liaw YP; Department of Public Health, Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Rd, Taichung City, 40201, Taiwan. Liawyp@csmu.edu.tw.
BMC Med Inform Decis Mak ; 24(1): 199, 2024 Jul 22.
Article en En | MEDLINE | ID: mdl-39039467
ABSTRACT

OBJECTIVE:

To develop and validate machine learning models for predicting coronary artery disease (CAD) within a Taiwanese cohort, with an emphasis on identifying significant predictors and comparing the performance of various models.

METHODS:

This study involved a comprehensive analysis of clinical, demographic, and laboratory data from 8,495 subjects in Taiwan Biobank (TWB) after propensity score matching to address potential confounding factors. Key variables included age, gender, lipid profiles (T-CHO, HDL_C, LDL_C, TG), smoking and alcohol consumption habits, and renal and liver function markers. The performance of multiple machine learning models was evaluated.

RESULTS:

The cohort comprised 1,699 individuals with CAD identified through self-reported questionnaires. Significant differences were observed between CAD and non-CAD individuals regarding demographics and clinical features. Notably, the Gradient Boosting model emerged as the most accurate, achieving an AUC of 0.846 (95% confidence interval [CI] 0.819-0.873), sensitivity of 0.776 (95% CI, 0.732-0.820), and specificity of 0.759 (95% CI, 0.736-0.782), respectively. The accuracy was 0.762 (95% CI, 0.742-0.782). Age was identified as the most influential predictor of CAD risk within the studied dataset.

CONCLUSION:

The Gradient Boosting machine learning model demonstrated superior performance in predicting CAD within the Taiwanese cohort, with age being a critical predictor. These findings underscore the potential of machine learning models in enhancing the prediction accuracy of CAD, thereby supporting early detection and targeted intervention strategies. TRIAL REGISTRATION Not applicable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Aprendizaje Automático Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Med Inform Decis Mak Asunto de la revista: INFORMATICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Aprendizaje Automático Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Med Inform Decis Mak Asunto de la revista: INFORMATICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido