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Alcohol consumption in relation to cognitive dysfunction and dementia: A systematic review and dose-response meta-analysis of comparative longitudinal studies.
Zarezadeh, Meysam; Mahmoudinezhad, Mahsa; Faghfouri, Amir Hossein; Mohammadzadeh Honarvar, Niyaz; Regestein, Quentin R; Papatheodorou, Stefania I; Mekary, Rania A; Willett, Walter C.
Afiliación
  • Zarezadeh M; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mahmoudinezhad M; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran; Department of Nutrition Science, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Faghfouri AH; Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
  • Mohammadzadeh Honarvar N; Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
  • Regestein QR; Department of Psychiatry, Brigham and Women's Hospital., 1249 Boylston St, Boston, MA 02215, USA.
  • Papatheodorou SI; Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, 02115, USA; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Boston, MA, 02115, USA.
  • Mekary RA; Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, 02115, USA; School of Pharmacy, MCPHS University, Boston, MA, 02115, USA. Electronic address: rania.mekary@mcphs.edu.
  • Willett WC; Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, 02115, USA. Electronic address: wwillett@hsph.harvard.edu.
Ageing Res Rev ; 100: 102419, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39038743
ABSTRACT

BACKGROUND:

Alcohol use is associated with a wide spectrum of neurological disorders, including cognitive dysfunction and dementia. Likewise, the high prevalence of cognitive dysfunction and dementia specifies the urgent need to identify modifiable risk factors. Because findings on alcohol and cognitive dysfunction and dementia have been inconsistent, the present dose-response meta-analysis of cohort and case control studies was conducted to evaluate the available evidence. METHOD AND MATERIALS A systematic search was conducted on PubMed/MEDLINE, Scopus, Embase, and PsychInfo databases and Google Scholar up to April, 2023. In the dose-response meta-analysis, a restricted cubic spline regression model was conducted to evaluate a possible non-linear relation between alcohol intake and the outcomes. Random-effects model was used to perform the meta-analysis and evaluate heterogeneity. Egger's test and a funnel plot were used to assess small study effects. Subgroup analyses were carried out to explore possible sources of heterogeneity.

RESULTS:

Seventeen eligible studies comprising 80,680 total persons with 4929 cases for dementia and 13,530 total persons with 1579 cases for cognitive dysfunction were included for dose-response analysis. When compared to the reference group of 0 g/day of alcohol intake, the dose-response meta-analysis revealed a significant non-linear (J-shaped) association between alcohol intake and the risk of each of cognitive dysfunction, (lower dose range 1-30.5 g/day, RR 0.97; 95 % CI 0.95-0.99; higher dose range >30.5 g/day, RR 1.07; 95 % CI 1.01-1.15) and dementia (lower dose range 1-17.5 g/day, RR 0.92; 95 % CI 0.88-0.96, higher dose range >17.5 g/day, RR 1.23; 95 % CI 1.09-1.35). The lowest risk was achieved at approximately 30 g/day of alcohol for cognitive dysfunction and 15 g/day for dementia. The J-shape association remained with subgroups defined by age (≤65; >65 years) or study duration (<10; ≥10 years) for dementia, and within age >65 and duration <10 years for cognitive dysfunction.

CONCLUSION:

We observed a J-shape association between alcohol consumption and both cognitive dysfunction and dementia, with light-to-moderate alcohol intake being associated with a reduced risk in adults. Further studies are needed to clarify more specifically the association between alcohol consumption and six domains of cognitive dysfunction based on diagnostic and statistical manual of mental disorders (DSM) criteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Demencia / Disfunción Cognitiva Límite: Aged / Humans / Middle aged Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Demencia / Disfunción Cognitiva Límite: Aged / Humans / Middle aged Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido