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Impact of procedural handling on the physiological effects of alfaxalone anaesthesia in the ball python (Python regius).
James, Lauren E; Bertelsen, Mads F; Wang, Tobias; Williams, Catherine J A.
Afiliación
  • James LE; Section for Zoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark.
  • Bertelsen MF; Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Copenhagen, Denmark.
  • Wang T; Section for Zoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark. Electronic address: https://twitter.com/Tobias_Wang_AU.
  • Williams CJA; Section for Zoophysiology, Department of Biology, Aarhus University, Aarhus, Denmark; Department of Animal and Veterinary Science, Aarhus University, Tjele, Denmark. Electronic address: catherine.williams@anivet.au.dk.
Comp Biochem Physiol A Mol Integr Physiol ; 297: 111704, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39038601
ABSTRACT
To describe the cardiovascular changes following intramuscular (handled) and intravascular (undisturbed, via intraarterial catheter) alfaxalone administration, we studied 20 healthy ball pythons (Python regius) in a randomised, prospective study. The pythons were instrumented with occlusive arterial catheters to facilitate undisturbed, continuous monitoring of heart rate and blood pressure. Six pythons were administered intramuscular (IM) saline, followed by 20 mg/kg IM alfaxalone, and were manually restrained for both injections. Six pythons received intraarterial (IA) saline, followed by 10 mg/kg IA alfaxalone, and remained undisturbed for both injections. Arterial blood samples were taken at 0, 12 and 60 min post-injection, and heart rate and blood pressure were recorded for 60 min. The remaining eight snakes received 20 mg/kg IM or 10 mg/kg IA alfaxalone (n = 4 per treatment) and were not handled for intubation 10 min post-injection, to examine the effects of handling during anaesthesia. IM administration of 20 mg/kg alfaxalone or an equivalent volume of saline elicited a profound tachycardia and hypertension, which recovered to resting values after 20 min. However, when 10 mg/kg alfaxalone or saline were injected IA, mild hypotension and a lower magnitude tachycardia occurred. Arterial PCO2 and PO2, pH and lactate concentrations did not change following IA alfaxalone, but an acidosis was observed during IM alfaxalone anaesthesia. There were no significant changes in plasma catecholamines and corticosterone among treatments. Handling for injection and during anaesthesia associated with intubation significantly affects cardiovascular parameters, whereas alfaxalone per se only elicits minor changes in cardiovascular physiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pregnanodionas / Presión Sanguínea / Boidae / Frecuencia Cardíaca Límite: Animals Idioma: En Revista: Comp Biochem Physiol A Mol Integr Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pregnanodionas / Presión Sanguínea / Boidae / Frecuencia Cardíaca Límite: Animals Idioma: En Revista: Comp Biochem Physiol A Mol Integr Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos