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A carboxymethyl-resistant starch/polyacrylic acid semi-IPN hydrogel with excellent adhesive and antibacterial properties for peri-implantitis prevention.
Li, Xiaoyan; Wei, Ailin; Zhao, Haosen; Wang, Zhenfei; Lyu, Yang; Nie, Jie; Chen, Yu.
Afiliación
  • Li X; School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
  • Wei A; School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
  • Zhao H; School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
  • Wang Z; School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
  • Lyu Y; School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
  • Nie J; Department of Cariology and Endodontology, Peking University School of Stomatology, Beijing, 100081, China. Electronic address: niejiepkuss@126.com.
  • Chen Y; School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China; Sports & Medicine Integration Research Center (SMIRC), Capital University of Physical Education and Sports, Beijing 100191, China. Electronic address: bityuchen@bit.edu.cn.
Colloids Surf B Biointerfaces ; 242: 114082, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39038412
ABSTRACT
Hydrogels possess inherent characteristics that render them promising for the prevention of peri-implantitis. Nonetheless, hydrogels with singular network structures are incapable of concurrently achieving the desired adhesion and mechanical properties. In this work, a carboxymethyl resistant starch/polyacrylic acid semi-interpenetrating (CMRS/PAA semi-IPN) hydrogel was successfully prepared in one step. Its morphology, structure, mechanical properties, and adhesion properties were systematically assessed, which revealed a homogeneously porous structure with a commendable mechanical strength of 67.317 kPa and an adhesion strength of 63 kPa. Ciprofloxacin (Cip) was loaded in the CMRS/PAA hydrogel via in situ compounding. The in vitro kinetic study of drug release shows that the slow drug release efficiency exceeds 90 % in the weakly acidic microenvironment at the infection site after 72 h, indicating enhanced antimicrobial properties. The Cip-loaded hydrogel also exhibits a remarkable bacterial inhibition rate exceeding 99 % against the pathogenic bacterium P. gingivalis and good cytocompatibility and hemocompatibility in vitro. In summary, the current work explored a novel solution and direction for the development of anti-infective medical materials applicable to dental implants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Almidón / Resinas Acrílicas / Hidrogeles / Periimplantitis / Antibacterianos Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Almidón / Resinas Acrílicas / Hidrogeles / Periimplantitis / Antibacterianos Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos