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Evaluation of bone mineral density (BMD) and trabecular bone score (TBS) in pheochromocytoma and paraganglioma; a multi-centric case-control study from India.
Patra, Shinjan; Boro, Hiya; Porchezhian, Pradakshna; Khan, Naila; Pande, Minal.
Afiliación
  • Patra S; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences Nagpur, Plot 2, Sector 20, Mihan, Nagpur, 441108, Maharashtra, India. shinjan100@gmail.com.
  • Boro H; Department of Endocrinology, Aadhar Health Institute, Hisar, 125001, Haryana, India.
  • Porchezhian P; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences Jodhpur, 2Nd Phase, M.I.A. Basni, Jodhpur, 342005, Rajasthan, India.
  • Khan N; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences Nagpur, Plot 2, Sector 20, Mihan, Nagpur, 441108, Maharashtra, India.
  • Pande M; Department of Endocrinology and Metabolism, All India Institute of Medical Sciences Nagpur, Plot 2, Sector 20, Mihan, Nagpur, 441108, Maharashtra, India.
Osteoporos Int ; 2024 Jul 22.
Article en En | MEDLINE | ID: mdl-39037490
ABSTRACT
Pheochromocytoma and paraganglioma (PPGL) have been associated with low bone mineral density (BMD) due to excess sympathetic system stimulation. Our study revealed low BMD and TBS (trabecular bone score) in cases compared to matched controls. Plasma-free nor-metanephrine and hypertension duration found to be most consistent predictive factors.

PURPOSE:

Pheochromocytoma and paraganglioma (PPGL) have been associated with low bone mineral density (BMD) and increased fracture risks. Sympathetic nervous system stimulation has been shown to increase bone resorption and decrease bone formation via ß2 receptors. Chronic inflammation and increased cytokine production add to more bone loss. TBS (trabecular bone score) is an established surrogate marker for bone histomorphometry. BMD and TBS data in pheochromocytoma and PPGL are scarce. The aim was to assess the BMD and TBS in pheochromocytoma and PPGL and look for clinical and biochemical predictors.

METHODS:

This case-control study had sample size of 58 (29 cases and controls each). BMI-, age-, and sex-matched controls were taken for comparison. Both cases and controls had undergone DXA scan and BMD {Z-scores and bone mineral concentration (BMC) in g/cm2} and TBS were analyzed. Detailed clinical histories and relevant biochemistry values were noted.

RESULTS:

The mean age of our case population was 29.5 ± 9.4 years with a mean age of HTN onset at 26.86 ± 6.6 years. Lumbar spine BMC (0.86 ± 0.14 vs 0.96 ± 0.15; p = 0.036), femoral neck Z-score (- 1.23 ± 1.07 vs - 0.75 ± 0.97; p = 0.003), and whole body BMC (0.91 ± 0.14 vs 1.07 ± 0.11; p = 0.000) were significantly low in cases compared to controls. Similarly, TBS was significantly lower in cases compared to controls (1.306 ± 0.113 vs 1.376 ± 0.083; p = 0.001).

CONCLUSION:

This study establishes both low bone mass and poor bone quality in an Indian pheochromocytoma and PPGL patient's cohort. Plasma-free nor-metanephrine and duration of hypertension were found to be most consistent predictive factors in multivariate regression analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Osteoporos Int Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Osteoporos Int Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido