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Triglyceride-Fasting Glucose Index and Homeostatic Model Assessment for Insulin Resistance as Predictors of Type 2 Diabetes Mellitus in South Indians With Normal Body Mass Index.
Ca, Jayashankar; Joshi, Amey; Ishaq, Mohammed; Adoor, Gurucharan; V, Mahesh; Jampugumpula, Harshavardhan; R, Kavitha; Sanjay, Bhangdiya G; Bhupathiraju, Prafulla K.
Afiliación
  • Ca J; Internal Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
  • Joshi A; Internal Medicine, University of Michigan Health-Sparrow, Lansing, USA.
  • Ishaq M; Internal Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
  • Adoor G; Internal Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
  • V M; Community and Family Medicine, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, IND.
  • Jampugumpula H; Internal Medicine, Manipal Hospital, Bangalore, IND.
  • R K; General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
  • Sanjay BG; Internal Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
  • Bhupathiraju PK; Internal Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
Cureus ; 16(6): e62742, 2024 Jun.
Article en En | MEDLINE | ID: mdl-39036225
ABSTRACT

INTRODUCTION:

 Early detection of type 2 diabetes mellitus (T2DM) is imperative to prevent the complications associated with the disease. Current guidelines for diagnosis rely on the assessment of serum glucose (fasting and post-prandial) and glycosylated hemoglobin (HbA1c) levels. Insulin resistance, a phenomenon associated with T2DM, has been observed before the changes in these metrics. The homeostatic model assessment for insulin resistance (HOMA-IR) has been widely used to assess the degree of insulin resistance. The triglyceride-fasting glucose (TyG) index is a newer marker of insulin resistance that merits further study. 

Aim:

The study aimed to assess the validity of the TyG index and HOMA-IR as markers for the development of T2DM in non-obese individuals.  Materials and

methods:

 One hundred eight non-obese patients without T2DM were included in this prospective cohort study and followed up for eight years. Anthropometric and biochemical parameters, including fasting glucose levels, HbA1c, fasting serum insulin, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG), were measured at enrolment and eight years follow-up, and HOMA-IR and TyG index were calculated. 

Results:

 Twenty participants out of 108 (18.5%) developed T2DM over eight years. On performing the area under the curve (AUC)-receiver operating characteristic curve analysis, TyG of >8.61 and HOMA-IR of >1.5 had the highest validity (ability) to predict new-onset T2DM in the study population (TyG AUC 0.612 (95% CI 0.514-0.705); HOMA-IR AUC 0.529 (95% CI 0.431-0.626)); however, this was not statistically significant. 

Conclusion:

 At an eight-year follow-up, TyG and HOMA-IR were unreliable predictors of the development of T2DM in non-obese individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos