New metabolites of 2-ethylhexyl salicylate in human urine after simulated real-life dermal sunscreen application.
Toxicol Lett
; 400: 1-8, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39034015
ABSTRACT
2-Ethylhexyl salicylate (EHS) is an organic UV filter which is used in sunscreen and other personal care products. The dermal uptake of EHS was studied in several dermal-exposure experiments. This paper aims to coherently assess urine samples after dermal exposure for the biomarkers EHS, 5OH-EHS, 5oxo-EHS, and 5cx-EPS as well as further biomarkers of interest, specifically 4OH-EHS, 4oxo-EHS, 2OH-EHS, and 6OH-EHS, for the first time. Samples from 18 participants of a pre-existing dermal exposure study under real-life conditions were reassessed using a comprehensive LC-MS/MS method. EHS accounts for 34â¯% of the cumulative excretion of all analytes within 24â¯h after exposure, followed by 5OH-EHS (19â¯%), 5cx-EPS (18â¯%), 4OH-EHS (15â¯%) and 5oxo-EHS (11â¯%). Further metabolites were only quantified in minor amounts. EHS as the most prominent excretion parameter in this study demonstrates the missing first-pass effect after dermal absorption. Furthermore, the applied novel comprehensive analytical procedure revealed oxidation at the ω (5cx-EPS, 6OH-EHS), ω-1 (5OH-EHS, 5oxo-EHS), and ω-2 positions (4OH-EHS, 4oxo-EHS) in the main chain of the ethylhexyl group as well as oxidation in the side chain (2OH-EHS). The presented data are of high relevance for a reliable toxicological risk assessment of dermal exposure to EHS.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Absorción Cutánea
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Protectores Solares
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Biomarcadores
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Salicilatos
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Espectrometría de Masas en Tándem
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Toxicol Lett
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos