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Supramolecular self-sensitized dual-drug nanoassemblies potentiating chemo-photodynamic therapy for effective cancer treatment.
Zhang, Xu; Lou, Xinyu; Qiao, Han; Jiang, Zhouyu; Sun, Hang; Shi, Xianbao; He, Zhonggui; Sun, Jin; Sun, Mengchi.
Afiliación
  • Zhang X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China.
  • Lou X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China.
  • Qiao H; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China.
  • Jiang Z; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China.
  • Sun H; Hong Kong Education University, Hong Kong SAR, 999077, China.
  • Shi X; Department of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.
  • He Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China.
  • Sun J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China. Electronic address: sunjin@syphu.edu.cn.
  • Sun M; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China. Electronic address: sunmengchi@syphu.edu.cn.
Int J Pharm ; 662: 124496, 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39033943
ABSTRACT
Chemo-photodynamic synergistic therapy (CPST) holds tremendous promise for treating cancers. Unfortunately, existing CPST applications suffer from complex synthetic procedures, low drug co-loading efficiency, and carrier-related toxicity. To address these issues, we have developed a supramolecular carrier-free self-sensitized nanoassemblies by co-assembling podophyllotoxin (PTOX) and chlorin e6 (Ce6) to enhance CPST efficiency against tumors. The nanoassemblies show stable co-assembly performance in simulative vivo neural environment (∼150 nm), with high co-loading ability for PTOX (72.2 wt%) and Ce6 (27.8 wt%). In vivo, the nanoassemblies demonstrate a remarkable ability to accumulate at tumor sites by leveraging the enhanced permeability and retention (EPR) effect. The disintegration of nanoassemblies following photosensitizer bioactivation triggered by the acidic tumor environment effectively resolves the challenge of aggregation-caused quenching (ACQ) effect. Upon exposure to external light stimulation, the disintegrated nanoassemblies not only illuminate cancer cells synergistically but also exert a more potent antitumor effect when compared with PTOX and Ce6 administered alone. This self-sensitized strategy represents a significant step forward in CPST, offering a unique co-delivery paradigm for clinic cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Podofilotoxina / Porfirinas / Clorofilidas / Fármacos Fotosensibilizantes / Nanopartículas Límite: Animals / Female / Humans Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Podofilotoxina / Porfirinas / Clorofilidas / Fármacos Fotosensibilizantes / Nanopartículas Límite: Animals / Female / Humans Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos