The economic burden of diseases and reproductive inefficiency in dairy cattle is evident and has been quantified. Dairy diseases and reproductive inefficiency are however associated with other issues as well, including animal welfare, environmental pressure, and public health risks. Quantifying these other issues is becoming important to help farmers making decisions. Quantification of the non-economic burdens of diseases and reproductive inefficiency is rare and lacks an overview of approaches and metrics. The first aim of this paper is to provide trends for associating diseases and reproductive inefficiency with economic and non-economic burdens of disease. The second aim is to provide a review of approaches and metrics used to quantify the non-economic burdens of disease and reproductive inefficiency. For the economic burden of diseases and reproductive performance, only an overview of the approaches used to quantify the burden is provided. The final aim is to propose approaches and metrics for future quantification of non-economic burdens caused by individual diseases. A literature search was conducted in Web of Science to identify scientific articles on mastitis, lameness, metabolic disorders and reproductive inefficiency in dairy cows. The search was restricted to articles published between 1 January 2010 and 31 December 2022 and resulted in 7,565 articles. The total number of articles that mentioned the economic, animal welfare, public health, and environmental burden was 1,253, 428, 291, and 77, respectively. An increase in the percentage of articles mentioning the economic, animal welfare, and public health burden is observed between 2010 and 2022. Despite the 2,049 articles that mentioned one of the burdens, the results showed that approximately 10% of the articles quantified one or more of these burdens. The economic burden of diseases and reproductive inefficiency has been quantified in 154 articles and very few articles quantified the non-economic burdens (9 articles for environment, 29 articles for public health and 2 articles for animal welfare). Eleven articles were identified that quantified multiple burdens, and in all these studies the economic burden was combined with a non-economic burden through a modeling approach (mainly simulation). We propose to link the non-economic burdens to biological simulation models, and thus develop bio-burden simulation models. Well-established approaches and metrics can be used to quantify economic, environmental, and public health burdens. For the economic impact, costs per cow per year can be assessed. A life cycle assessment can be performed for environmental impact and the public health impact can be assessed by a defined daily dose for antimicrobial use and disability-adjusted life years for zoonotic diseases. Regarding animal welfare, approaches and metrics to quantify the welfare impact of a diseased animal are not well established. For animal welfare, we propose a welfare-adjusted life years approach. The mentioned approaches and metrics are a proposal, and it is up to the scientific community to use them or, based on empirics and research experience, propose changes so that we will end up with robust approaches and metrics that enable us to compare research results and provide more evidence for animal health decision makers.