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The role of mesenchymal stem cells in the treatment and pathogenesis of psoriasis.
Chen, Yan-Kun; Mohamed, Asma'a H; Amer Alsaiari, Ahad; Olegovich Bokov, Dmitry; Ali Patel, Ayyub; Al Abdulmonem, Waleed; Shafie, Alaa; Adnan Ashour, Amal; Azhar Kamal, Mohammad; Ahmad, Fuzail; Ahmad, Irshad.
Afiliación
  • Chen YK; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518109, China; Precision Medicine R&D Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519000, China.
  • Mohamed AH; Biomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babil 51001, Hilla, Iraq. Electronic address: asmaa_hassan@uomus.edu.iq.
  • Amer Alsaiari A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Olegovich Bokov D; Institute of Pharmacy Named After A.P. Nelyubin, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow 119991, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow 109240, Russia
  • Ali Patel A; Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Al Abdulmonem W; Department of Pathology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
  • Shafie A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Adnan Ashour A; Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Azhar Kamal M; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia.
  • Ahmad F; Respiratory Care Department, College of Applied Sciences, Almaarefa University, Diriya, Riyadh 13713, Saudi Arabia.
  • Ahmad I; Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. Electronic address: iabdulhamed@kku.edu.sa.
Cytokine ; 182: 156699, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39033730
ABSTRACT
Psoriasis, a prevalent inflammatory skin condition impacting millions globally, continues to pose treatment challenges, despite the availability of multiple therapies. This underscores the demand for innovative treatments. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option due to their capacity to modulate the immune system and facilitate tissue healing. Recent research indicates that MSCs don't just work through direct cell-to-cell interactions but also release extracellular vesicles (EVs), containing various bioactive substances like proteins, lipids, and nucleic acids. This article explores our current knowledge of psoriasis's origins and the potential utilization of MSCs and their EVs, particularly exosomes, in managing the condition. Additionally, we delve into how MSCs and EVs function in therapy, including their roles in regulating immune responses and promoting tissue repair. Lastly, we discuss the obstacles and opportunities associated with translating MSC-based treatments for psoriasis into clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Trasplante de Células Madre Mesenquimatosas / Exosomas / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Trasplante de Células Madre Mesenquimatosas / Exosomas / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido