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The Effect of Adding Daily 50 mg Intramuscular Progesterone to 800 mg Progesterone Suppository on The In Vitro Fertilization Success Rate in Women with Low Progesterone Levels: A Clinical Trial Study.
Ebrahimi, Mahbod; Akbari Asbagh, Firoozeh; Davari Tanha, Fatemeh; Amirkhanloo, Fatemeh; Sahraiyan, Ghazal; Feizabad, Elham; Lotfi, Sara.
Afiliación
  • Ebrahimi M; Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Akbari Asbagh F; Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Davari Tanha F; Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Amirkhanloo F; Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Sahraiyan G; Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Feizabad E; Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Lotfi S; Department of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Fertil Steril ; 18(Suppl 1): 55-59, 2024 Jul 13.
Article en En | MEDLINE | ID: mdl-39033371
ABSTRACT

BACKGROUND:

A low progesterone level on the embryo transfer (ET) day significantly reduces the pregnancy rate. Therefore, the present study aims to investigate the effect of adding daily 50 mg intramuscular progesterone to a total of 800 mg progesterone suppository on the in vitro fertilization (IVF) success rate in women with low progesterone levels. MATERIALS AND

METHODS:

This parallel open-label clinical trial was performed on 218 IVF candidate infertile women who had <9.2 ng/ml progesterone levels on the ET day. These women were randomised to the intervention or control group using the randomisation allocation rule. In the intervention group, 50 mg progesterone was prescribed intramuscularly once daily in addition to 400 mg of progesterone suppository every 12 hours from the day of ET. The control group received only 400 mg of progesterone suppositories every 12 hours. In the case of pregnancy, the drugs above were continued until 12 weeks after the ET.

RESULTS:

Clinical pregnancy occurred in 54 (50.0%) women in the intervention group and in 39 (36.8%) women in the control group, which was significantly different (P=0.035). Ongoing pregnancy occurred in 47 (43.5%) women in the intervention group, and 33 (31.1%) women in the control group, which was significantly different (P=0.042). There were no significant differences in terms of abortion and multiple pregnancy rates between the two groups.

CONCLUSION:

Intramuscular injection of 50 mg progesterone significantly increases the clinical and ongoing pregnancy rates (registration number IRCT20150105020558N6).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Fertil Steril Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Fertil Steril Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán