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Association of pregnancy complications and postpartum maternal leukocyte telomeres in two diverse cohorts: a nested case-control study.
Panelli, Danielle M; Wang, Xiaobin; Mayo, Jonathan; Wong, Ronald J; Hong, Xiumei; Becker, Martin; Aghaeepour, Nima; Druzin, Maurice L; Zuckerman, Barry S; Stevenson, David K; Shaw DrPH, Gary M; Bianco, Katherine.
Afiliación
  • Panelli DM; Division of Maternal-Fetal Medicine and Obstetrics, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Center for Academic Medicine, Obstetrics and Gynecology, MC 5317, 453 Quarry Road, Stanford, CA, 94304, USA. dpanelli@stanford.edu.
  • Wang X; Center on the Early Life Origins of Disease, Departments of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Mayo J; Division of Maternal-Fetal Medicine and Obstetrics, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Center for Academic Medicine, Obstetrics and Gynecology, MC 5317, 453 Quarry Road, Stanford, CA, 94304, USA.
  • Wong RJ; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Hong X; Center on the Early Life Origins of Disease, Departments of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Becker M; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Aghaeepour N; Department of Computer Science and Electrical Engineering, University of Rostock, Rostock, Germany.
  • Druzin ML; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Zuckerman BS; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Stevenson DK; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
  • Shaw DrPH GM; Division of Maternal-Fetal Medicine and Obstetrics, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Center for Academic Medicine, Obstetrics and Gynecology, MC 5317, 453 Quarry Road, Stanford, CA, 94304, USA.
  • Bianco K; Department of Pediatrics, Boston Medical Center, Boston, MA, USA.
BMC Pregnancy Childbirth ; 24(1): 490, 2024 Jul 20.
Article en En | MEDLINE | ID: mdl-39033276
ABSTRACT

BACKGROUND:

Biologic strain such as oxidative stress has been associated with short leukocyte telomere length (LTL), as well as with preeclampsia and spontaneous preterm birth, yet little is known about their relationships with each other. We investigated associations of postpartum maternal LTL with preeclampsia and spontaneous preterm birth.

METHODS:

This pilot nested case control study included independent cohorts of pregnant people with singleton gestations from two academic institutions Cohort 1 (hereafter referred to as Suburban) were enrolled prior to 20 weeks' gestation between 2012 and 2018; and Cohort 2 (hereafter referred to as Urban) were enrolled at delivery between 2000 and 2012. Spontaneous preterm birth or preeclampsia were the selected pregnancy complications and served as cases. Cases were compared with controls from each study cohort of uncomplicated term births. Blood was collected between postpartum day 1 and up to 6 months postpartum and samples were frozen, then simultaneously thawed for analysis. Postpartum LTL was the primary outcome, measured using quantitative polymerase chain reaction (PCR) and compared using linear multivariable regression models adjusting for maternal age. Secondary analyses were done stratified by mode of delivery and self-reported level of stress during pregnancy.

RESULTS:

156 people were included; 66 from the Suburban Cohort and 90 from the Urban Cohort. The Suburban Cohort was predominantly White, Hispanic, higher income and the Urban Cohort was predominantly Black, Haitian, and lower income. We found a trend towards shorter LTLs among people with preeclampsia in the Urban Cohort (6517 versus 6913 bp, p = 0.07), but not in the Suburban Cohort. There were no significant differences in LTLs among people with spontaneous preterm birth compared to term controls in the Suburban Cohort (6044 versus 6144 bp, p = 0.64) or in the Urban Cohort (6717 versus 6913, p = 0.37). No differences were noted by mode of delivery. When stratifying by stress levels in the Urban Cohort, preeclampsia was associated with shorter postpartum LTLs in people with moderate stress levels (p = 0.02).

CONCLUSION:

Our exploratory results compare postpartum maternal LTLs between cases with preeclampsia or spontaneous preterm birth and controls in two distinct cohorts. These pilot data contribute to emerging literature on LTLs in pregnancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Nacimiento Prematuro / Periodo Posparto / Leucocitos Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Nacimiento Prematuro / Periodo Posparto / Leucocitos Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: BMC Pregnancy Childbirth Asunto de la revista: OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido