Your browser doesn't support javascript.
loading
Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour.
Ratsika, Anna; Codagnone, Martin G; Bastiaanssen, Thomaz F S; Hoffmann Sarda, Fabiana A; Lynch, Caoimhe M K; Ventura-Silva, Ana Paula; Rosell-Cardona, Cristina; Caputi, Valentina; Stanton, Catherine; Fülling, Christine; Clarke, Gerard; Cryan, John F.
Afiliación
  • Ratsika A; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
  • Codagnone MG; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
  • Bastiaanssen TFS; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
  • Hoffmann Sarda FA; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
  • Lynch CMK; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
  • Ventura-Silva AP; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland.
  • Rosell-Cardona C; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland.
  • Caputi V; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland.
  • Stanton C; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
  • Fülling C; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland.
  • Clarke G; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12YT20, Ireland.
  • Cryan JF; APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12YT20, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland. Electronic address: j.cryan@ucc.ie.
Brain Behav Immun ; 121: 317-330, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39032541
ABSTRACT
The developing central nervous system is highly sensitive to nutrient changes during the perinatal period, emphasising the potential impact of alterations of maternal diet on offspring brain development and behaviour. A growing body of research implicates the gut microbiota in neurodevelopment and behaviour. Maternal overweight and obesity during the perinatal period has been linked to changes in neurodevelopment, plasticity and affective disorders in the offspring, with implications for microbial signals from the maternal gut. Here we investigate the impact of maternal high-fat diet (mHFD)-induced changes in microbial signals on offspring brain development, and neuroimmune signals, and the enduring effects on behaviour into adolescence. We first demonstrate that maternal caecal microbiota composition at term pregnancy (embryonic day 18 E18) differs significantly in response to maternal diet. Moreover, mHFD resulted in the upregulation of microbial genes in the maternal intestinal tissue linked to alterations in quinolinic acid synthesis and elevated kynurenine levels in the maternal plasma, both neuronal plasticity mediators related to glutamate metabolism. Metabolomics of mHFD embryonic brains at E18 also detected molecules linked to glutamate-glutamine cycle, including glutamic acid, glutathione disulphide, and kynurenine. During adolescence, the mHFD offspring exhibited increased locomotor activity and anxiety-like behaviour in a sex-dependent manner, along with upregulation of glutamate-related genes compared to controls. Overall, our results demonstrate that maternal exposure to high-fat diet results in microbiota changes, behavioural imprinting, altered brain metabolism, and glutamate signalling during critical developmental windows during the perinatal period.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Encéfalo / Dieta Alta en Grasa / Microbioma Gastrointestinal Límite: Animals / Pregnancy Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Encéfalo / Dieta Alta en Grasa / Microbioma Gastrointestinal Límite: Animals / Pregnancy Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Países Bajos