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High levels of plasma neurofilament light chain correlated with brainstem and peripheral nerve damage.
Nakamura, Takumi; Kawarabayashi, Takeshi; Shibata, Makoto; Kasahara, Hiroo; Makioka, Kouki; Sugawara, Takashi; Oka, Hironori; Ishizawa, Kunihiko; Amari, Masakuni; Ueda, Tetsuya; Kinoshita, Seiji; Miyamoto, Yuka; Kaito, Kozue; Takatama, Masamitsu; Ikeda, Yoshio; Shoji, Mikio.
Afiliación
  • Nakamura T; Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan. Electronic address: takumi.n@gunma-u.ac.jp.
  • Kawarabayashi T; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
  • Shibata M; Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Kasahara H; Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Makioka K; Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Sugawara T; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
  • Oka H; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
  • Ishizawa K; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
  • Amari M; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
  • Ueda T; Bioanalysis Department, Mediford Corporation, Tokyo, Japan.
  • Kinoshita S; Bioanalysis Department, Mediford Corporation, Tokyo, Japan.
  • Miyamoto Y; Bioanalysis Department, Mediford Corporation, Tokyo, Japan.
  • Kaito K; Bioanalysis Department, Mediford Corporation, Tokyo, Japan.
  • Takatama M; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
  • Ikeda Y; Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Shoji M; Department of Neurology, Geriatrics Research Institute and Hospital, Gunma, Japan.
J Neurol Sci ; 463: 123137, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39032446
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Blood neurofilament light chain (NfL) is a minimally invasive, but highly sensitive biomarker of neurological diseases. However, diseases and neurological damage associated with increased NfL remain unclear. Therefore, the present study investigated factors associated with increased plasma NfL levels in various neurological diseases, focal lesions and pathological processes.

METHODS:

This was a retrospective cohort study on 410 participants with various neurological diseases and 17 healthy and cognitively unimpaired controls (HCU). Plasma samples were analyzed to measure NfL using ECL immunoassay. The focal lesions were classified as the cerebrum, cerebellum, brainstem, meninges, spinal cord, peripheral nerves, neuromuscular junction, and muscles based on medical records. A multiple regression analysis and receiver operating characteristic curve (ROC) analysis were performed to investigate whether plasma NfL levels predict specific diseases and focal lesions.

RESULTS:

Plasma NfL levels discriminated between the HCU and all disease groups (area under the curve (AUC), 0.97), with a cut-off value of 63.4 pg/mL. A multiple regression analysis of focal lesions adjusted by pathogenic processes showed that brainstem and peripheral nerve involvement was associated with higher plasma NfL levels. A cut-off value of 53.8 pg/mL of NfL discriminated between the HCU and neurological disease group except for brainstem or peripheral disorders (AUC 0.962), while a cut-off value of 208.0 pg/mL distinguished this group from brainstem or peripheral nervous system disorders (AUC 0.716).

DISCUSSION:

These results demonstrate that plasma NfL has a potential to be a highly sensitive biomarker for neurological diseases and focal lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tronco Encefálico / Proteínas de Neurofilamentos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tronco Encefálico / Proteínas de Neurofilamentos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos