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Carbon Dots in Photodynamic Therapy: The Role of Dopant and Solvent on Optical and Photo-Responsive Properties.
Wibowo, Agung; Khan, Mohd Jahir; Sansanaphongpricha, Kanokwan; Khemthong, Pongtanawat; Laosiripojana, Navadol; Yu, Yu Sheng; Wu, Kevin C W; Sakdaronnarong, Chularat.
Afiliación
  • Wibowo A; Mahidol University Faculty of Engineering, Chemical Engineering, Department of Chemical Engineering, Mahidol University, 25/25 Putthamonthon 4 Road,Salaya, Putthamonthon, 73170, Putthamonthon, THAILAND.
  • Khan MJ; Mahidol University Faculty of Engineering, Chemical Engineering, Department of Chemical Engineering, Mahidol University, 25/25 Putthamonthon 4 Road,Salaya, Putthamonthon, 73170, Putthamonthon, THAILAND.
  • Sansanaphongpricha K; National Science and Technology Development Agency, National Nanotechnology Center, 111 Thailand Science Park, Phahonyothin Rd, Klong Nueng,, Klong Luang,, 12120, THAILAND.
  • Khemthong P; National Science and Technology Development Agency, National Nanotechnology Center, 111 Thailand Science Park, Phahonyothin Rd, Klong Nueng,, Klong Luang,, 12120, THAILAND.
  • Laosiripojana N; King Mongkut's University of Technology Thonburi, The Joint Graduate School of Energy and Environment, 126 Pracha Uthit Road, Bang Mot, 10140, Thung Khru, THAILAND.
  • Yu YS; National Taiwan University, Chemical Engineering, No.1, Sec.4 Roosevelt Road, 10617, Taipei, TAIWAN.
  • Wu KCW; National Taiwan University, Chemical Engineering, No.1, Sec.4 Roosevelt Road, 10617, Taipei, TAIWAN.
  • Sakdaronnarong C; Mahidol University Faculty of Engineering, Chemical Engineering, 25/25 Putthamonthon 4 Road, Salaya, Putthamonthon, 73170, Nakorn Pathom, THAILAND.
Chemistry ; : e202400885, 2024 Jul 20.
Article en En | MEDLINE | ID: mdl-39032088
ABSTRACT
Carbon dots (CDs) are novel carbon-based luminescent materials with wide-ranging applications in biosensing, bioimaging, drug transportation, optical devices, and beyond. Their advantageous attributes, including biocompatibility, biodegradability, antioxidant activity, photostability, small particle size (< 10 nm), and strong light absorption and excitation across a broad range of wavelengths, making them promising candidates in the field of photodynamic therapy (PDT) as photosensitizers (PSs). Further enhancements in functionality are imperative to enhance the effectiveness of CDs in PDT applications, notwithstanding their inherent benefits. Recently, doping agents and solvents have been demonstrated to improve CDs' optical properties, solubility, cytotoxicity, and organelle targeting efficiency. These improvements result from modifications to the CDs' carbon skeleton matrices, functional groups on the surface state, and chemical structures. This review discusses the modification of CDs with heteroatom dopants, dye dopants, and solvents to improve their physicochemical and optical properties for PDT applications. The correlations between the surface chemistry, functional groups, structure of the CDs and their optical characteristics toward quantum yield, redshift feature and reactive oxygen species generation, have also been discussed. Finally, the progressive trends for the use of CDs in PDT applications are also addressed in this review.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Alemania
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Alemania