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Applications of Nanopore sequencing in precision cancer medicine.
Dyshlovoy, Sergey A; Paigin, Stefanie; Afflerbach, Ann-Kristin; Lobermeyer, Annabelle; Werner, Stefan; Schüller, Ulrich; Bokemeyer, Carsten; Schuh, Anna H; Bergmann, Lina; von Amsberg, Gunhild; Joosse, Simon A.
Afiliación
  • Dyshlovoy SA; Department of Oncology, Oxford Molecular Diagnostics Centre, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, UK.
  • Paigin S; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Afflerbach AK; Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lobermeyer A; Institute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
  • Werner S; Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schüller U; Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bokemeyer C; Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schuh AH; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
  • Bergmann L; Institute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • von Amsberg G; Department of Paediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Joosse SA; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Int J Cancer ; 155(12): 2129-2140, 2024 Dec 15.
Article en En | MEDLINE | ID: mdl-39031959
ABSTRACT
Oxford Nanopore Technologies sequencing, also referred to as Nanopore sequencing, stands at the forefront of a revolution in clinical genetics, offering the potential for rapid, long read, and real-time DNA and RNA sequencing. This technology is currently making sequencing more accessible and affordable. In this comprehensive review, we explore its potential regarding precision cancer diagnostics and treatment. We encompass a critical analysis of clinical cases where Nanopore sequencing was successfully applied to identify point mutations, splice variants, gene fusions, epigenetic modifications, non-coding RNAs, and other pivotal biomarkers that defined subsequent treatment strategies. Additionally, we address the challenges of clinical applications of Nanopore sequencing and discuss the current efforts to overcome them.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicina de Precisión / Secuenciación de Nanoporos / Neoplasias Límite: Humans Idioma: En Revista: Int J Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicina de Precisión / Secuenciación de Nanoporos / Neoplasias Límite: Humans Idioma: En Revista: Int J Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos