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Overexpression of the receptor for resolvin E1 (ERV1) prevents early alveolar bone loss in leptin receptor deficiency-induced diabetes.
Suárez, Lina J; Hasturk, Hatice; Tubero Euzebio Alves, Vanessa; Díaz-Baez, David; Van Dyke, Thomas; Kantarci, Alpdogan.
Afiliación
  • Suárez LJ; ADA Forsyth Institute, Cambridge, Massachusetts, USA.
  • Hasturk H; Universidad Nacional de Colombia, Bogotá, Colombia.
  • Tubero Euzebio Alves V; ADA Forsyth Institute, Cambridge, Massachusetts, USA.
  • Díaz-Baez D; Harvard University, Boston, Massachusetts, USA.
  • Van Dyke T; ADA Forsyth Institute, Cambridge, Massachusetts, USA.
  • Kantarci A; University of Kentucky, Lexington, Kentucky, USA.
J Periodontol ; 2024 Jun 21.
Article en En | MEDLINE | ID: mdl-39031577
ABSTRACT

BACKGROUND:

This study was designed to test the hypothesis that the leptin receptor (LepR) regulates changes in periodontal tissues and that the overexpression of the receptor for resolvin E1 (ERV1) prevents age- and diabetes-associated alveolar bone loss.

METHODS:

LepR-deficient transgenic (TG) mice were cross-bred with those overexpressing ERV1 (TG) to generate double-TG mice. In total, 95 mice were divided into four experimental groups wild type (WT), TG, LepR deficient (db/db), and double transgenic (db/db TG). The groups were followed from 4 weeks up to 16 weeks of age. The natural progression of periodontal disease without any additional method of periodontitis induction was assessed by macroscopic and histomorphometric analyses. Osteoclastic activity was measured by tartrate-resistant acid phosphatase (TRAP) staining.

RESULTS:

At 4 weeks, ERV1 overexpression prevented weight gain. From Week 8 onward, there was a significant increase in the weight of db/db mice with or without ERV1 overexpression compared to the WT mice, accompanied by an increase in glucose levels. By 8 weeks of age, the percentage of bone loss in the LepR deficiency groups was significantly greater compared to WT mice. ERV1 overexpression in the db/db TG mice prevented early alveolar bone loss; however, it did not impact the development of diabetic bone loss in aging mice after the onset of weight gain and diabetes.

CONCLUSIONS:

The findings suggest that the overexpression of ERV1 prevents LepR-associated alveolar bone loss during the early phases of periodontal disease by delaying weight gain, diabetes onset, and associated inflammation; however, LepR deficiency increases susceptibility to naturally occurring inflammatory alveolar bone loss as the animal ages, associated with excess weight gain, onset of diabetes, and excess inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Periodontol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Periodontol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos