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Spontaneous regression of primary cutaneous diffuse large B-cell lymphoma, leg type: A case series and review of the literature.
Winkler, Manuel; Albrecht, Jana Dorothea; Sauer, Christian; Kordaß, Theresa; Guenova, Emmanuella; Livingstone, Elisabeth; Wobser, Marion; Mitteldorf, Christina; Géraud, Cyrill; Nicolay, Jan Peter.
Afiliación
  • Winkler M; Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Albrecht JD; Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Sauer C; Clinical Cooperation Unit Dermato-Oncology, German Cancer Research Center, Heidelberg, Germany.
  • Kordaß T; Section of Clinical and Experimental Dermatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Guenova E; Institute of Pathology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Livingstone E; Institute of Pathology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Wobser M; Department of Dermatology, Lausanne University Hospital, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
  • Mitteldorf C; Department of Dermatology, Venereology, and Allergology, University Hospital Essen, Essen, Germany.
  • Géraud C; Department of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Würzburg, Germany.
  • Nicolay JP; Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
J Dermatol ; 51(9): 1233-1239, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39031169
ABSTRACT
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) is a subtype of cutaneous B-cell lymphoma with unfavorable prognosis usually requiring aggressive polychemotherapy for disease control. Only single cases of spontaneous regression of PCDLBCL, LT are reported in the literature, peaking 3 months post-biopsy following a clinical history of no longer than 1 year. Here, we report the first case of a spontaneously relapsing and remitting PCDLBCL, LT with complete regression after a clinical history of more than 9 years and thus an atypically indolent clinical course. The female patient presented with recurrent erythematous, non-ulcerated, non-raised plaques of the right lower leg for 6 years. Pathological workup and exclusion of a systemic disease confirmed the diagnosis of PCDLBCL, LT. Due to the history of repeated spontaneous remission, no therapy was initiated. Nine years after first occurrence the patient presented with complete clinical remission lasting for 64 months. We retrospectively identified four additional PCDLBCL, LT patients with spontaneous remission lasting up to 53 months. Our data provide evidence for a distinct PCDLBCL, LT patient subgroup that clinicians should be aware of and warrants a watch-and-wait treatment regime.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Linfoma de Células B Grandes Difuso / Pierna / Regresión Neoplásica Espontánea Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: J Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Linfoma de Células B Grandes Difuso / Pierna / Regresión Neoplásica Espontánea Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: J Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido