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Meta-Analysis Comparing Drug-Coated Balloon Versus Plain Old Balloon Angioplasty for In-Stent Restenosis of Coronary Arteries.
Shaikh, Safia; Hamza, Mohammad; Upreti, Prakash; Akkawi, Mohammad; Rajak, Kripa; Haider, Mobeen Zaka; Kumar, Nomesh; Turkmani, Mustafa; Kathawa, Fadi; Basit, Salman Abdul; Bahar, Yasemin; Fakhra, Sadaf; Sattar, Yasar; Alraies, M Chadi.
Afiliación
  • Shaikh S; Division of Hospital Medicine, Washington University in St. Louis, St Louis, Missouri.
  • Hamza M; Department of Internal Medicine, Guthrie Medical Group, Cortland, New York.
  • Upreti P; Sands Constellation Heart Institute, Rochester Regional Health, Rochester, New York.
  • Akkawi M; Department of Internal Medicine, Detroit Medical Center/Sinai Grace, Wayne State University, Detroit, Michigan.
  • Rajak K; Department of Internal Medicine, University of Pittsburgh Medical Center, Harrisburg, Pennsylvania.
  • Haider MZ; Department of Internal Medicine, Carle Foundation Hospital, Carle Illinois College of Medicine, Urbana, Illinois.
  • Kumar N; Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan.
  • Turkmani M; Department of Internal Medicine, McLaren Healthcare Oakland, Pontiac, Michigan.
  • Kathawa F; Department of Internal Medicine, Detroit Medical Center/Wayne State University, Detroit, Michigan.
  • Basit SA; The Wright Center for GME, Scranton, Pennsylvania.
  • Bahar Y; Wayne State University, Detroit, Michigan.
  • Fakhra S; University of Nevada, Las Vegas-Kirk Kerkorian School of Medicine, Las Vegas, Nevada.
  • Sattar Y; Department of Cardiology, West Virginia University, Morgantown, West Virginia.
  • Alraies MC; Cardiovascular Institute, Detroit Medical Center, Detroit, Michigan. Electronic address: alraies@hotmail.com.
Am J Cardiol ; 229: 22-27, 2024 Oct 15.
Article en En | MEDLINE | ID: mdl-39029724
ABSTRACT
Despite the advent of newer stents, in-stent restenosis has been a persistent and formidable challenge. Trials have demonstrated the superiority of drug-coated balloons over plain old balloon angioplasty. A recent AGENT IDE PRESTO (Prevention of REStenosis with Tranilast and its Outcomes) trial highlighted the need for a more comprehensive understanding; therefore, we conducted a meta-analysis to elucidate their respective clinical outcomes. A literature search was conducted by 2 investigators (SS and MH) using MEDLINE (EMBASE and PubMed) using a systematic search strategy by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) until November 1, 2023. CRAN-R software was used for statistical analysis. The quality assessment was performed using the Cochrane Risk of Bias tool (Supplementary Table 5). We included 6 studies with a total of 1,171 patients. Our analysis showed decreased odds of multiple outcomes with statistically significant results, including target vessel revascularization (odds ratio [OR] 0.33, confidence interval [CI] 0.19 to 0.57), target vessel failure (OR 0.30, CI 0.09 to 0.99), target lesion revascularization (OR 0.22, CI 0.10 to 0.46), restenosis (OR 0.1343, CI 0.06 to 0.27), and major adverse cardiac events (OR 0.2 CI 0.12 to 0.37). Although myocardial infraction and all-cause mortality showed decreased odds with all-cause mortality at 0.8 (95% CI 0.363 to 2.09), and myocardial infarction at 0.6 (95% CI 0.0349 to 1.07), the reductions did not reach statistical significance. Our analysis by scrutinizing 6 randomized controlled trials favored drug-coated balloons over plain old balloon angioplasty. However, extensive research for deeper understanding cannot be overemphasized.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioplastia Coronaria con Balón / Materiales Biocompatibles Revestidos / Reestenosis Coronaria Límite: Humans Idioma: En Revista: Am J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angioplastia Coronaria con Balón / Materiales Biocompatibles Revestidos / Reestenosis Coronaria Límite: Humans Idioma: En Revista: Am J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos