Carbetocin versus oxytocin for the prevention of postpartum haemorrhage during caesarean section in patients at high risk of bleeding.
Eur J Obstet Gynecol Reprod Biol
; 300: 206-210, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39029242
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of carbetocin versus oxytocin in preventing postpartum haemorrhage (PPH) in women with risk factors for PPH who were delived by caesarean section.METHODS:
This retrospective, monocentric, before-and-after cohort study assessed patients with haemorrhagic risk factors who underwent caesarean section after 24 weeks of gestation and who had haemorrhagic risk factors between August 2014 to December 2019.RESULTS:
This study enrolled 518 patients, including 250 in the oxytocin group and 268 in the carbetocin group. The use of carbetocin was independently associated with a PPH decrease compared to oxytocin use (adjusted odds ratio [OR] 0.52; 95 % confidence interval [CI] 0.35-0.79; p = 0.002). Carbetocin use was associated with a reduction in the need for therapy escalation (6 % vs 10.8 %; p = 0.046).CONCLUSION:
Carbetocin was more effective than oxytocin in preventing PPH after caesarean section in high-risk patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxitócicos
/
Oxitocina
/
Cesárea
/
Hemorragia Posparto
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Irlanda