Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9.
Medicine (Baltimore)
; 103(29): e38855, 2024 Jul 19.
Article
en En
| MEDLINE
| ID: mdl-39029066
ABSTRACT
OBJECTIVE:
This study investigated the intervention effect of slow-velocity eccentric-only resistance training on type 2 diabetic mellitus (T2DM) patients based on the role of matrix metalloproteinase-2 and -9 (MMP-2 and -9) in regulating extracellular matrix homeostasis.METHODS:
50 T2DM patients were randomly divided into the slow-velocity eccentric-only resistance training group (E) and control group (C). The E group performed eccentric-only resistance training 3 times a week, every other day for 10 weeks, while the C group did not. Blood samples were collected before and after training, and subjects were tested for changes in clinical parameters, insulin resistance indices [fasting insulin, homeostatic model assessment insulin resistance (HOMA-IR)], MMP-2 and -9, and hydroxyproline, and muscle strength (12-RM), respectively.RESULTS:
After 10 weeks of training, the E group showed significant decreases in fasting glucose (Pâ <â .05), insulin (Pâ <â .05), insulin resistance indices (Pâ <â .05), hemoglobin A1c (HbA1c) (Pâ <â .01), triglycerides (Pâ =â .06) and MMP-2 (Pâ <â .05), while total cholesterol (Pâ <â .05), MMP-9 (Pâ <â .05), hydroxyproline (Pâ <â .01), Creatine Kinase (CK) (Pâ <â .05), and muscle strength (Pâ <â .001) significantly increased. There were no significant changes in the count of neutrophil, lymphocyte and platelet, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). Compared with the C group, the E group showed a trend of a significant decrease in triglyceride (Pâ <â .05), lymphocyte count (Pâ <â .05), fasting glucose (Pâ =â .07), and plasma MMP-2 (Pâ <â .05), while MMP-9 (Pâ <â .05), hydroxyproline (Pâ <â .001), and muscle strength (Pâ <â .01) significantly increased. However, no significant changes were observed in insulin and insulin resistance indices, HbA1c, total cholesterol, HDL-c, LDL-c, CK, and other inflammatory indicators.CONCLUSIONS:
Slow-velocity eccentric-only resistance training was beneficial for T2DM, but the potential role of MMP-2 and -9 in regulating extracellular matrix homeostasis is very different in T2DM patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Metaloproteinasa 2 de la Matriz
/
Metaloproteinasa 9 de la Matriz
/
Diabetes Mellitus Tipo 2
/
Fuerza Muscular
/
Entrenamiento de Fuerza
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos