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Bruch's Membrane Opening Changes in Eyes With Myopic Macular Degeneration: AIER-SERI Adult High Myopia Study.
Wu, Linli; Foo, Li-Lian; Hu, Ziqi; Pan, Wei; Jiang, Yanfeng; Saw, Seang-Mei; Hoang, Quan V; Lan, Weizhong.
Afiliación
  • Wu L; Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
  • Foo LL; Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore.
  • Hu Z; Aier Eye Hospital Group, Changsha, China.
  • Pan W; Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
  • Jiang Y; Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, China.
  • Saw SM; Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore.
  • Hoang QV; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Lan W; Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore.
Invest Ophthalmol Vis Sci ; 65(8): 36, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-39028975
ABSTRACT

Purpose:

The purpose of this study was to assess the choroidal thickness and the Bruch's membrane opening size and their relationship to visual acuity in eyes with myopic macular degeneration (MMD).

Methods:

This was a population-based, cross-sectional study. Patients over the age of 30 years with high myopia (spherical equivalent ≤-5 diopters [D]) were recruited. The eyes were grouped according to the International Meta-Analysis for Pathologic Myopia (META-PM) classification based on fundus photographs and diffuse atrophy was subdivided into peripapillary diffuse choroidal atrophy (PDCA) or macular diffuse choroidal atrophy (MDCA). Swept-source optical coherence tomography imaging was performed and then the subfoveal choroidal thickness (SFCT) and Bruch's membrane opening diameter (BMOD) were measured.

Results:

Of the 470 study participants recruited, 373 patients (691 eyes), with a mean age of 42.8 ± 7.2 years, were eligible for the study and included in the analysis. There was no significant difference in SFCT between MDCA and patchy atrophy (M3) groups (P = 1.000), and the BMOD enlarged significantly from no myopic macular lesions to M3 (the P values of multiple comparison tests were all <0.005). Simple linear regression analysis showed that BMOD correlated positively with age (P < 0.001) and axial length (P < 0.001). Multiple linear regression analysis showed that best corrected visual acuity (BCVA) was significantly correlated with age (P = 0.041), axial length (P = 0.001), and BMOD (P = 0.017), but not with SFCT (P = 0.231).

Conclusions:

The significant variation of BMOD among MMD groups and the correlation between BMOD and BCVA in MMD eyes suggest that BMOD may be an imaging biomarker for monitoring MMD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agudeza Visual / Lámina Basal de la Coroides / Tomografía de Coherencia Óptica / Miopía Degenerativa / Degeneración Macular Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agudeza Visual / Lámina Basal de la Coroides / Tomografía de Coherencia Óptica / Miopía Degenerativa / Degeneración Macular Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos