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Catecholamine concentration as a predictor of mortality in emergency surgical patients.
Suh, João Isuk; da Roza, Daiane Leite; Cadamuro, Filipe Matheus; Malbouisson, Luiz Marcelo Sá; Sanches, Talita Rojas; Andrade, Lúcia.
Afiliación
  • Suh JI; Nephrology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
  • da Roza DL; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil.
  • Cadamuro FM; Trauma Intensive Care Unit, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
  • Malbouisson LMS; Trauma Intensive Care Unit, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
  • Sanches TR; Nephrology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
  • Andrade L; Nephrology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil. lucia.andrade@fm.usp.br.
Int J Emerg Med ; 17(1): 95, 2024 Jul 18.
Article en En | MEDLINE | ID: mdl-39026158
ABSTRACT

BACKGROUND:

Trauma and emergency surgery are major causes of morbidity and mortality. The objective of this study was to determine whether serum levels of epinephrine and norepinephrine are associated with aging and mortality.

METHODS:

This was a prospective observational cohort study conducted in a surgical critical care unit. We included 90 patients who were admitted for postoperative care, because of major trauma, or both. We collected demographic and clinical variables, as well as serum levels of epinephrine and norepinephrine.

RESULTS:

For patients in the > 60-year age group, the use of vasoactive drugs was found to be associated with an undetectable epinephrine level (OR [95% CI] = 6.36 [1.12, 36.08]), p = 0.05). For the patients with undetectable epinephrine levels, the in-hospital mortality was higher among those with a norepinephrine level ≥ 2006.5 pg/mL (OR [95% CI] = 4.00 [1.27, 12.58]), p = 0.03).

CONCLUSIONS:

There is an association between age and mortality. Undetectable serum epinephrine, which is more common in older patients, could contribute to poor outcomes. The use of epinephrine might improve the clinical prognosis in older surgical patients with shock.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Emerg Med Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Emerg Med Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido